biostudies-literatureUnknown8(1)Nosheny RLEfficient identification of cognitive decline and Alzheimer's disease (AD) risk in early stages of the AD disease continuum is a critical unmet need. Subjective cognitive decline is increasingly recognized as an early symptomatic stage of AD. Dyadic cognitive report, including subjective cognitive complaints (SCC) from a participant and an informant/study partner who knows the participant well, represents an accurate, reliable, and efficient source of data for assessing risk. However, the separate and combined contributions of self- and study partner report, and the dynamic relationship between the two, remains unclear. The Subjective Cognitive Decline Professional Interest Area within the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment convened Alzheimer's & dementia (New York, N. Y.)e12357https://www.ebi.ac.uk/biostudies/studies/S-EPMC9530696biostudies-literatureThe role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations.PMC9530696Sanchez-Benavides GDyadic Patterns of Subjective Report working group within the Subjective Cognitive Decline Professional Interest Area, Alzheimer's Association ISTAARTSellek Rodriguez AFKuhn EAaronson AZawaly KUrwyler PPereiro AXBrucki SMDKasuga KIsmail ZSikkes SAMAmariglio RDowling NMNosheny RLMoretti DVBicalho MACVan Hulle CNumbers KfalseThe role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations.Efficient identification of cognitive decline and Alzheimer's disease (AD) risk in early stages of the AD disease continuum is a critical unmet need. Subjective cognitive decline is increasingly recognized as an early symptomatic stage of AD. Dyadic cognitive report, including subjective cognitive complaints (SCC) from a participant and an informant/study partner who knows the participant well, represents an accurate, reliable, and efficient source of data for assessing risk. However, the separate and combined contributions of self- and study partner report, and the dynamic relationship between the two, remains unclear. The Subjective Cognitive Decline Professional Interest Area within the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment convened 2022-01-01T00:00:00Z20222025-04-05T12:18:39.338Z2025-04-05T12:18:39.338ZS-EPMC95306963622604610.1002/trc2.12357