biostudies-literatureLee YBMinistry of Trade, Industry and EnergyMinistry of EducationMinistry of Science and ICTMinistry of Food and Drug SafetyKorea Medical Device Development FundKorea Health Industry Development InstituteMinistry of Health and WelfareNational Research Foundation of Korea722-732https://www.ebi.ac.uk/biostudies/studies/S-EPMC9532170biostudies-literatureUnknown46(5)<h4>Background</h4>We assessed the myocardial infarction (MI), stroke, and all-cause death risks during follow-up according to the low-density lipoprotein cholesterol (LDL-C) levels among older adults.<h4>Methods</h4>The Korean National Health Insurance Service datasets (2002 to 2020) were used for this population-based cohort study. The hazards of MI, stroke, and all-cause mortality during follow-up were analyzed according to LDL-C level in individuals aged ≥65 years without baseline cardiovascular diseases (n=1,391,616).<h4>Results</h4>During a mean 7.55 years, 52,753 MIs developed; 84,224 strokes occurred over a mean 7.47 years. After a mean 8.50 years, 233,963 died. A decrease in LDL-C was associated with lower hazards of MI and stroke. The decreased hazard of stroke in lower LDL-C wasDiabetes & metabolism journalMyocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study.PMC9532170KMDF_PR_20200901_02339991007469, KMDF_PR_20200901_0233R21065419991007469HR20C0021Lee YBNoh EHwang SYChoi KMRoh EYoo HJCho GJKoo MKim JAHong SHBaik SHfalseMyocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study.<h4>Background</h4>We assessed the myocardial infarction (MI), stroke, and all-cause death risks during follow-up according to the low-density lipoprotein cholesterol (LDL-C) levels among older adults.<h4>Methods</h4>The Korean National Health Insurance Service datasets (2002 to 2020) were used for this population-based cohort study. The hazards of MI, stroke, and all-cause mortality during follow-up were analyzed according to LDL-C level in individuals aged ≥65 years without baseline cardiovascular diseases (n=1,391,616).<h4>Results</h4>During a mean 7.55 years, 52,753 MIs developed; 84,224 strokes occurred over a mean 7.47 years. After a mean 8.50 years, 233,963 died. A decrease in LDL-C was associated with lower hazards of MI and stroke. The decreased hazard of stroke in lower LDL-C was2022-01-01T00:00:00Z2022 Sep2025-04-05T11:37:49.562Z2025-04-05T11:37:49.562ZS-EPMC95321703525555210.4093/dmj.2021.0225