{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang T"],"funding":["National Health and Medical Research Council of Australia","Australian Research Council"],"pagination":["781-802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9532183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(5)"],"pubmed_abstract":["<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.<h4>Methods</h4>PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.<h4>Results</h4>A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contribute"],"journal":["Diabetes & metabolism journal"],"pubmed_title":["Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis."],"pmcid":["PMC9532183"],"funding_grant_id":["130101705","120100227","1063907"],"pubmed_authors":["Shaw M","Zhang T","Cherbuin N"],"additional_accession":[]},"is_claimable":false,"name":"Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis.","description":"<h4>Background</h4>Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.<h4>Methods</h4>PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.<h4>Results</h4>A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contribute","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T23:20:38.921Z","creation":"2025-04-04T23:20:38.921Z"},"accession":"S-EPMC9532183","cross_references":{"pubmed":["35255549"],"doi":["10.4093/dmj.2021.0189"]}}