biostudies-literatureUnknown12(1)Jeran SThe purpose of the study was to develop prediction models to estimate physical activity (PA)-related energy expenditure (AEE) based on accelerometry and additional variables in free-living adults. In 50 volunteers (20-69 years) PA was determined over 2 weeks using the hip-worn Actigraph GT3X + as vector magnitude (VM) counts/minute. AEE was calculated based on total daily EE (measured by doubly-labeled water), resting EE (indirect calorimetry), and diet-induced thermogenesis. Anthropometry, body composition, blood pressure, heart rate, fitness, sociodemographic and lifestyle factors, PA habits and food intake were assessed. Prediction models were developed by context-grouping of 75 variables, and within-group stepwise selection (stage I). All significant variables were jointly offered for Scientific reports16578https://www.ebi.ac.uk/biostudies/studies/S-EPMC9532429biostudies-literaturePrediction of activity-related energy expenditure under free-living conditions using accelerometer-derived physical activity.PMC9532429Haas VWesterterp KRBruhmann BAMahler APischon TJeran SSteinbrecher ABoschmann MSteindorf KfalsePrediction of activity-related energy expenditure under free-living conditions using accelerometer-derived physical activity.The purpose of the study was to develop prediction models to estimate physical activity (PA)-related energy expenditure (AEE) based on accelerometry and additional variables in free-living adults. In 50 volunteers (20-69 years) PA was determined over 2 weeks using the hip-worn Actigraph GT3X + as vector magnitude (VM) counts/minute. AEE was calculated based on total daily EE (measured by doubly-labeled water), resting EE (indirect calorimetry), and diet-induced thermogenesis. Anthropometry, body composition, blood pressure, heart rate, fitness, sociodemographic and lifestyle factors, PA habits and food intake were assessed. Prediction models were developed by context-grouping of 75 variables, and within-group stepwise selection (stage I). All significant variables were jointly offered for 2022-01-01T00:00:00Z2022 Oct2025-04-04T13:46:19.583Z2025-04-04T13:46:19.583ZS-EPMC95324293619564710.1038/s41598-022-20639-0