biostudies-literatureUnknown11(5)Farrell SW<h4>Background</h4>We examined the associations of cardiorespiratory fitness (CRF) and white blood cell count (WBC) with mortality outcomes.<h4>Methods</h4>A total of 52,056 apparently healthy adults completed a comprehensive health examination, including a maximal treadmill test and blood chemistry analyses. CRF was categorized as high, moderate, or low by age and sex; WBC was categorized as sex-specific quartiles.<h4>Results</h4>During 17.8 ± 9.5 years (mean ± SD) of follow-up, a total of 4088 deaths occurred. When regressed jointly, significantly decreased all-cause mortality across CRF categories was observed within each quartile of WBC in men. Within WBC Quartile 1, all-cause mortality hazard ratios (HRs) with a 95% confidence interval (95%CI) were 1.0 (referent), 1.29 (95%CI: 1.06‒1.Journal of sport and health science605-612https://www.ebi.ac.uk/biostudies/studies/S-EPMC9532609biostudies-literatureCardiorespiratory fitness, white blood cell count, and mortality in men and women.PMC9532609Shuval KLeonard DHaskell WLFarrell SWBarlow CEDeFina LFPavlovic AfalseCardiorespiratory fitness, white blood cell count, and mortality in men and women.<h4>Background</h4>We examined the associations of cardiorespiratory fitness (CRF) and white blood cell count (WBC) with mortality outcomes.<h4>Methods</h4>A total of 52,056 apparently healthy adults completed a comprehensive health examination, including a maximal treadmill test and blood chemistry analyses. CRF was categorized as high, moderate, or low by age and sex; WBC was categorized as sex-specific quartiles.<h4>Results</h4>During 17.8 ± 9.5 years (mean ± SD) of follow-up, a total of 4088 deaths occurred. When regressed jointly, significantly decreased all-cause mortality across CRF categories was observed within each quartile of WBC in men. Within WBC Quartile 1, all-cause mortality hazard ratios (HRs) with a 95% confidence interval (95%CI) were 1.0 (referent), 1.29 (95%CI: 1.06‒1.2022-01-01T00:00:00Z2022 Sep2025-04-21T16:50:14.18Z2025-04-05T11:38:14.213ZS-EPMC95326093474087210.1016/j.jshs.2021.10.005