{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang Y"],"funding":["National Natural Science Foundation of China"],"pagination":["854250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9532862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Understanding the signaling pathway regulatory mechanisms in type II alveolar epithelial (ATII) cells, the progenitor cells responsible for proliferating and regenerating type I alveolar epithelial (ATI) and ATII cells, in Tibetan pigs is beneficial for exploring methods of preventing and repairing cellular damage during hypoxia. We simulated a hypoxic environment (2% O<sub>2</sub>) for culture ATII cells of Tibetan pigs and Landrace pigs, with cells cultured under normoxic conditions (21% O<sub>2</sub>) as a control group, and performed integrated analysis of circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory axes by whole-transcriptome sequencing. Functional enrichment analysis indicated that the source genes of the differential expressed circRNAs (DEcircRNAs) were p"],"journal":["Frontiers in molecular biosciences"],"pubmed_title":["Characterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs."],"pmcid":["PMC9532862"],"funding_grant_id":["32060730 31760644"],"pubmed_authors":["Liu X","Li Y","Yang Y","Zhao S","Ren Y","Cai Y","Jiao T","Yuan H","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs.","description":"Understanding the signaling pathway regulatory mechanisms in type II alveolar epithelial (ATII) cells, the progenitor cells responsible for proliferating and regenerating type I alveolar epithelial (ATI) and ATII cells, in Tibetan pigs is beneficial for exploring methods of preventing and repairing cellular damage during hypoxia. We simulated a hypoxic environment (2% O<sub>2</sub>) for culture ATII cells of Tibetan pigs and Landrace pigs, with cells cultured under normoxic conditions (21% O<sub>2</sub>) as a control group, and performed integrated analysis of circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) regulatory axes by whole-transcriptome sequencing. Functional enrichment analysis indicated that the source genes of the differential expressed circRNAs (DEcircRNAs) were p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T11:41:34.707Z","creation":"2024-11-07T00:31:48.045Z"},"accession":"S-EPMC9532862","cross_references":{"pubmed":["36213124"],"doi":["10.3389/fmolb.2022.854250"]}}