{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berry KA"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NIDDK NIH HHS","NIA NIH HHS","National Institutes of Health","National Institute on Aging"],"pagination":["100718"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9533335"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(5)"],"pubmed_abstract":["<h4>Introduction</h4>Loneliness, \"a subjective feeling of being isolated\", is a strong predictor of adverse health. We characterized loneliness in patients with end-stage liver disease (ESLD) awaiting liver transplantation (LT).<h4>Methods</h4>We surveyed loneliness in ambulatory ESLD adults awaiting LT at 7 U.S. sites using the validated UCLA Three-Item Loneliness Scale, May2020-Jan2021; \"lonely\"=total ≥5. Liver Frailty Index (LFI) assessed frailty; \"frail\"=LFI≥4.4. Logistic regression associated loneliness and co-variables.<h4>Results</h4>Of 454 participants, median MELDNa was 14 (IQR 10-19) and 26% met criteria for \"lonely\". Compared to those not lonely, those lonely were younger (57 v. 61y), more likely to be female (48% v. 31%) or frail (21 v. 11%), and less likely to be working (15% v. 26%) or in a committed partnership (52% v. 71%). After multivariable adjustment, frailty (OR=2.24, 95%CI=1.23-4.08), younger age (OR=1.19, 95%CI=1.07-1.34), female sex (OR=1.83, 95%CI=1.14-2.92), not working (OR=2.16, 95%CI=1.16-4.03), and not in a committed partnership (OR=2.07, 95%CI=1.29-3.32) remained significantly associated with higher odds of loneliness.<h4>Conclusion</h4>Loneliness is prevalent in adults awaiting LT, and independently associated with younger age, female sex and physical frailty. These data lay the foundation to investigate the extent to which loneliness impacts health outcomes in LT, as in the general population. Clinical Trial Registry Website: https://clinicaltrials.gov Trial Number: NCT03228290."],"journal":["Annals of hepatology"],"pubmed_title":["Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers."],"pmcid":["PMC9533335"],"funding_grant_id":["P30 DK026743","KL2 TR001870","K23 AG048337","R01 AG059183","R01AG059183/K23AG048337","F32 DK124941","TL1 TR001871","K24DK101828","K24 DK101828","P30 DK132710","F32DK124941","KL2TR001870"],"pubmed_authors":["Volk ML","Wong R","Seetharaman S","Berry KA","Nunez-Duarte M","Ladner DP","Kappus MR","Wadhwani SI","Ganger DR","McAdams-DeMarco M","Lai JC","Boyarsky BJ","Verna EC","Rahimi RS","Kent D","Duarte-Rojo A","Mohamad Y","Segev DL","Yao F"],"additional_accession":[]},"is_claimable":false,"name":"Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers.","description":"<h4>Introduction</h4>Loneliness, \"a subjective feeling of being isolated\", is a strong predictor of adverse health. We characterized loneliness in patients with end-stage liver disease (ESLD) awaiting liver transplantation (LT).<h4>Methods</h4>We surveyed loneliness in ambulatory ESLD adults awaiting LT at 7 U.S. sites using the validated UCLA Three-Item Loneliness Scale, May2020-Jan2021; \"lonely\"=total ≥5. Liver Frailty Index (LFI) assessed frailty; \"frail\"=LFI≥4.4. Logistic regression associated loneliness and co-variables.<h4>Results</h4>Of 454 participants, median MELDNa was 14 (IQR 10-19) and 26% met criteria for \"lonely\". Compared to those not lonely, those lonely were younger (57 v. 61y), more likely to be female (48% v. 31%) or frail (21 v. 11%), and less likely to be working (15% v. 26%) or in a committed partnership (52% v. 71%). After multivariable adjustment, frailty (OR=2.24, 95%CI=1.23-4.08), younger age (OR=1.19, 95%CI=1.07-1.34), female sex (OR=1.83, 95%CI=1.14-2.92), not working (OR=2.16, 95%CI=1.16-4.03), and not in a committed partnership (OR=2.07, 95%CI=1.29-3.32) remained significantly associated with higher odds of loneliness.<h4>Conclusion</h4>Loneliness is prevalent in adults awaiting LT, and independently associated with younger age, female sex and physical frailty. These data lay the foundation to investigate the extent to which loneliness impacts health outcomes in LT, as in the general population. Clinical Trial Registry Website: https://clinicaltrials.gov Trial Number: NCT03228290.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep-Oct","modification":"2025-05-29T16:10:33.191Z","creation":"2025-04-05T22:20:47.649Z"},"accession":"S-EPMC9533335","cross_references":{"pubmed":["35460882"],"doi":["10.1016/j.aohep.2022.100718"]}}