{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(5)"],"submitter":["Boehm I"],"pubmed_abstract":["Background
It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted food intake, because diminished levels of the tryptophan precursor lower the central availability of serotonin (5-HT). At the neural level, the salience network is a system of functionally connected brain regions; it has been closely associated with 5-HT functioning and mental disorders (including anorexia nervosa). The aim of the present study was to investigate the effect on the salience network of a temporary dietary manipulation of 5-HT synthesis in patients with anorexia nervosa.Methods
In this double-blind crossover study, we obtained data on resting-state functional conne"],"journal":["Journal of psychiatry & neuroscience : JPN"],"pagination":["E351-E358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9533767"],"repository":["biostudies-literature"],"pubmed_title":["Acute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa."],"pmcid":["PMC9533767"],"pubmed_authors":["Ehrlich S","Boehm I","Roessner V","Hennig J","Geisler D","Ritschel F","King JA","Lesch I","Zepf FD"],"additional_accession":[]},"is_claimable":false,"name":"Acute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa.","description":"Background
It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted food intake, because diminished levels of the tryptophan precursor lower the central availability of serotonin (5-HT). At the neural level, the salience network is a system of functionally connected brain regions; it has been closely associated with 5-HT functioning and mental disorders (including anorexia nervosa). The aim of the present study was to investigate the effect on the salience network of a temporary dietary manipulation of 5-HT synthesis in patients with anorexia nervosa.Methods
In this double-blind crossover study, we obtained data on resting-state functional conne","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep-Oct","modification":"2025-04-26T22:08:04.872Z","creation":"2025-04-06T17:06:11.203Z"},"accession":"S-EPMC9533767","cross_references":{"pubmed":["36195339"],"doi":["10.1503/jpn.210161"]}}