biostudies-literatureUnknown47(5)Boehm I<h4>Background</h4>It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted food intake, because diminished levels of the tryptophan precursor lower the central availability of serotonin (5-HT). At the neural level, the salience network is a system of functionally connected brain regions; it has been closely associated with 5-HT functioning and mental disorders (including anorexia nervosa). The aim of the present study was to investigate the effect on the salience network of a temporary dietary manipulation of 5-HT synthesis in patients with anorexia nervosa.<h4>Methods</h4>In this double-blind crossover study, we obtained data on resting-state functional conneJournal of psychiatry & neuroscience : JPNE351-E358https://www.ebi.ac.uk/biostudies/studies/S-EPMC9533767biostudies-literatureAcute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa.PMC9533767Ehrlich SBoehm IRoessner VHennig JGeisler DRitschel FKing JALesch IZepf FDfalseAcute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa.<h4>Background</h4>It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted food intake, because diminished levels of the tryptophan precursor lower the central availability of serotonin (5-HT). At the neural level, the salience network is a system of functionally connected brain regions; it has been closely associated with 5-HT functioning and mental disorders (including anorexia nervosa). The aim of the present study was to investigate the effect on the salience network of a temporary dietary manipulation of 5-HT synthesis in patients with anorexia nervosa.<h4>Methods</h4>In this double-blind crossover study, we obtained data on resting-state functional conne2022-01-01T00:00:00Z2022 Sep-Oct2025-04-26T22:08:04.872Z2025-04-06T17:06:11.203ZS-EPMC95337673619533910.1503/jpn.210161