{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huynh MV"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["eabn2694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9534304"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(746)"],"pubmed_abstract":["Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly<sup>12</sup>, Gly<sup>13</sup>, and Gln<sup>61</sup> (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61 mutations in <i>KRAS</i> are infrequent and differ markedly in occurrence. Q61H is the predominant mutant (at 57%), followed by Q61R/L/K (collectively 40%), and Q61P and Q61E are the rarest (2 and 1%, respectively). Probability analysis suggested that mutational susceptibility to different DNA base changes cannot account for this distribution. Therefore, we investigated whether these frequencies might be explained by differences in the biochemical, structural, and biological properties of KRAS<sup>Q61</sup> mutants. Expression of KRAS<sup>Q61</"],"journal":["Science signaling"],"pubmed_title":["Functional and biological heterogeneity of KRAS<sup>Q61</sup> mutations."],"pmcid":["PMC9534304"],"funding_grant_id":["P01 CA203657","R35 GM134962","F32 CA200313","R01 CA213775","R01 CA232372","T32 CA009156","R01 CA175747","U01 CA199235","R01 CA042978","P30 CA016086","P50 CA196510","P20 GM130457","R35 CA232113","F30 CA243253","T32 CA071341"],"pubmed_authors":["Campbell SL","Pierobon M","Diehl JN","Carey LM","Huynh MV","Cooke AR","Waters AM","Simeone DM","Goodwin CM","Cook JH","Cox AD","Hobbs GA","Thurman RD","DeLiberty JM","Schaefer A","Der CJ","Lin L","Petricoin EF","Lyssiotis CA","Haigis KM","Rashid NU"],"additional_accession":[]},"is_claimable":false,"name":"Functional and biological heterogeneity of KRAS<sup>Q61</sup> mutations.","description":"Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly<sup>12</sup>, Gly<sup>13</sup>, and Gln<sup>61</sup> (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61 mutations in <i>KRAS</i> are infrequent and differ markedly in occurrence. Q61H is the predominant mutant (at 57%), followed by Q61R/L/K (collectively 40%), and Q61P and Q61E are the rarest (2 and 1%, respectively). Probability analysis suggested that mutational susceptibility to different DNA base changes cannot account for this distribution. Therefore, we investigated whether these frequencies might be explained by differences in the biochemical, structural, and biological properties of KRAS<sup>Q61</sup> mutants. Expression of KRAS<sup>Q61</","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-27T21:01:49.964Z","creation":"2025-02-19T04:20:47.442Z"},"accession":"S-EPMC9534304","cross_references":{"pubmed":["35944066"],"doi":["10.1126/scisignal.abn2694"]}}