{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forst CV"],"funding":["NIAID NIH HHS","DBT/Wellcome Trust India Alliance","Wellcome Trust"],"pagination":["eabm5859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9534503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(40)"],"pubmed_abstract":["Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection-induced pathways including cell cycle and interferon (IFN) signaling. <i>TDRD7</i> is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species. <i>TDRD7</i> is required for antiviral IFN res"],"journal":["Science advances"],"pubmed_title":["Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans."],"pmcid":["PMC9534503"],"funding_grant_id":["U01 AI111598","75N93021C00014","U19 AI106754","U19 AI168631","R21 AI149013","IA/I/18/1/503613","U19 AI142733","U19 AI135972"],"pubmed_authors":["Lashua L","Dos Anjos Borges LG","Carter CE","Garcia-Sastre A","Pache L","Wang G","Rodriguez-Frandsen A","Chanda SK","Tripathi S","Zhou X","Ghedin E","Ross TM","Wang M","Forst CV","Moulton H","Martin-Sancho L","White KM","Ding T","Geber A","Metreveli G","Stein DA","Zhang B","Urbanowski MD","Shaw ML"],"additional_accession":[]},"is_claimable":false,"name":"Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans.","description":"Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection-induced pathways including cell cycle and interferon (IFN) signaling. <i>TDRD7</i> is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species. <i>TDRD7</i> is required for antiviral IFN res","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-27T11:59:17.864Z","creation":"2024-11-13T14:24:32.796Z"},"accession":"S-EPMC9534503","cross_references":{"pubmed":["36197970"],"doi":["10.1126/sciadv.abm5859"]}}