{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(40)"],"submitter":["Zhao B"],"pubmed_abstract":["Synovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a concept of the photocatalytic regulation of SME is proposed for arthritis treatment, and monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed by a full-solution method to achieve near infrared-photocatalytic generation of hydrogen molecules and simultaneous depletion of overexpressed lactic acid (LA) for realizing SME regulation in a collagen-induced mouse model of rheumatoid arthritis. Mechanistically, locally generated hydrogen molecules scavenge overexpressed reactive oxygen species to mediate the anti-inflammatory polarization of macrophages, while the simultaneous photocat"],"journal":["Science advances"],"pagination":["eabq0959"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9534508"],"repository":["biostudies-literature"],"pubmed_title":["NIR-photocatalytic regulation of arthritic synovial microenvironment."],"pmcid":["PMC9534508"],"pubmed_authors":["Li G","Zhao B","Zeng L","Tang W","He Q","Jin Z","Xie S","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"NIR-photocatalytic regulation of arthritic synovial microenvironment.","description":"Synovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a concept of the photocatalytic regulation of SME is proposed for arthritis treatment, and monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed by a full-solution method to achieve near infrared-photocatalytic generation of hydrogen molecules and simultaneous depletion of overexpressed lactic acid (LA) for realizing SME regulation in a collagen-induced mouse model of rheumatoid arthritis. Mechanistically, locally generated hydrogen molecules scavenge overexpressed reactive oxygen species to mediate the anti-inflammatory polarization of macrophages, while the simultaneous photocat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-31T22:51:40.065Z","creation":"2024-11-10T06:36:56.679Z"},"accession":"S-EPMC9534508","cross_references":{"pubmed":["36197972"],"doi":["10.1126/sciadv.abq0959"]}}