biostudies-literatureUnknown8(40)Zhao BSynovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a concept of the photocatalytic regulation of SME is proposed for arthritis treatment, and monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed by a full-solution method to achieve near infrared-photocatalytic generation of hydrogen molecules and simultaneous depletion of overexpressed lactic acid (LA) for realizing SME regulation in a collagen-induced mouse model of rheumatoid arthritis. Mechanistically, locally generated hydrogen molecules scavenge overexpressed reactive oxygen species to mediate the anti-inflammatory polarization of macrophages, while the simultaneous photocatScience advanceseabq0959https://www.ebi.ac.uk/biostudies/studies/S-EPMC9534508biostudies-literatureNIR-photocatalytic regulation of arthritic synovial microenvironment.PMC9534508Li GZhao BZeng LTang WHe QJin ZXie SChen DfalseNIR-photocatalytic regulation of arthritic synovial microenvironment.Synovial microenvironment (SME) plays a vital role in the formation of synovial pannus and the induction of cartilage destruction in arthritis. In this work, a concept of the photocatalytic regulation of SME is proposed for arthritis treatment, and monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed by a full-solution method to achieve near infrared-photocatalytic generation of hydrogen molecules and simultaneous depletion of overexpressed lactic acid (LA) for realizing SME regulation in a collagen-induced mouse model of rheumatoid arthritis. Mechanistically, locally generated hydrogen molecules scavenge overexpressed reactive oxygen species to mediate the anti-inflammatory polarization of macrophages, while the simultaneous photocat2022-01-01T00:00:00Z2022 Oct2025-05-31T22:51:40.065Z2024-11-10T06:36:56.679ZS-EPMC95345083619797210.1126/sciadv.abq0959