{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lim JME"],"funding":["Ministry of Health -Singapore","National Medical Research Council"],"pagination":["100793"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9534788"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(11)"],"pubmed_abstract":["Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here, we perform a comparative analysis of SARS-CoV-2-specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to spike mRNA vaccination, inactivated vaccines elicit a lower magnitude of spike-specific T cells, but the combination of membrane, nucleoprotein, and spike-specific T cell response is quantitatively comparable with the sole spike T cell response induced by mRNA vaccine, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein-specific T cell response i"],"journal":["Cell reports. Medicine"],"pubmed_title":["A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines."],"pmcid":["PMC9534788"],"funding_grant_id":["COVID19RF3-0060","COVID19RF-008","COVID19RF-001"],"pubmed_authors":["Lye DC","Chia A","Hang SK","Tan N","Chng E","Lim JME","Lim PL","Le Bert N","Young BE","Lee ES","Tan AT","Bertoletti A","Hariharaputran S"],"additional_accession":[]},"is_claimable":false,"name":"A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines.","description":"Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here, we perform a comparative analysis of SARS-CoV-2-specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to spike mRNA vaccination, inactivated vaccines elicit a lower magnitude of spike-specific T cells, but the combination of membrane, nucleoprotein, and spike-specific T cell response is quantitatively comparable with the sole spike T cell response induced by mRNA vaccine, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein-specific T cell response i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T01:12:40.191Z","creation":"2024-10-18T22:32:10.972Z"},"accession":"S-EPMC9534788","cross_references":{"pubmed":["36257326"],"doi":["10.1016/j.xcrm.2022.100793"]}}