{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lou W"],"funding":["Youth Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission, China","Zhejiang Medical and Health Science and Technology Plan","Zhejiang Provincial Natural Science Foundation of China","National Natural Science Foundation of China","Science and Technology Program of Zhejiang Province"],"pagination":["94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9535888"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["The tumor microenvironment (TME) is characterized by discrete changes in metabolic features of cancer and immune cells, with various implications. Cancer cells take up most of the available glucose to support their growth, thereby leaving immune cells with insufficient nutrients to expand. In the relative absence of glucose, T cells switch the metabolic program to lipid-based sources, which is pivotal to T-cell differentiation and activation in nutrient-stressed TME. Although consumption of lipids should provide an alternative energy source to starving T cells, a literature survey has revealed that it may not necessarily lead to antitumor responses. Different subtypes of T cells behave differently in various lipid overload states, which widely depends upon the kind of free fatty acids (FFA"],"journal":["Lipids in health and disease"],"pubmed_title":["Lipid metabolic features of T cells in the Tumor Microenvironment."],"pmcid":["PMC9535888"],"funding_grant_id":["LQ21H160009","LGF19H290002","2021KY409","82103334","XWKYHT20200047","81901625"],"pubmed_authors":["Zhu M","Gong C","Fang Z","Hu Y","Lou W","Xu H","Ye Z"],"additional_accession":[]},"is_claimable":false,"name":"Lipid metabolic features of T cells in the Tumor Microenvironment.","description":"The tumor microenvironment (TME) is characterized by discrete changes in metabolic features of cancer and immune cells, with various implications. Cancer cells take up most of the available glucose to support their growth, thereby leaving immune cells with insufficient nutrients to expand. In the relative absence of glucose, T cells switch the metabolic program to lipid-based sources, which is pivotal to T-cell differentiation and activation in nutrient-stressed TME. Although consumption of lipids should provide an alternative energy source to starving T cells, a literature survey has revealed that it may not necessarily lead to antitumor responses. Different subtypes of T cells behave differently in various lipid overload states, which widely depends upon the kind of free fatty acids (FFA","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T22:36:11.632Z","creation":"2025-02-19T00:27:17.818Z"},"accession":"S-EPMC9535888","cross_references":{"pubmed":["36203151"],"doi":["10.1186/s12944-022-01705-y"]}}