{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong Chong E"],"funding":["This project was funded with an establishment grant for new investigators of the Oncology research axis from the CHU de Québec."],"pagination":["1049"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9535963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background / synopsis</h4>Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to peripheral cells. Little is known on the role, if any, of circulating lipid-related factors such as PCSK9, ANGPTL3 and lipoprotein (a) in cancers.<h4>Objective/purpose</h4>To compare circulating levels of PCSK9, ANGPTL3, and Lp(a) in women with stage III breast cancer versus women with premalignant or benign breast lesions.<h4>Methods</h4>Twenty-three plasma samples from women diagnosed with a stage III breast cancer (ductal, lobular or mixed) were matched for age with twenty-three plasma samples from women bearing premalignant (stage 0, n = 9) or benign (n"],"journal":["BMC cancer"],"pubmed_title":["Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers."],"pmcid":["PMC9535963"],"funding_grant_id":["NA"],"pubmed_authors":["Gangloff A","Joncas FH","Seidah NG","Wong Chong E","Calon F","Diorio C"],"additional_accession":[]},"is_claimable":false,"name":"Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers.","description":"<h4>Background / synopsis</h4>Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to peripheral cells. Little is known on the role, if any, of circulating lipid-related factors such as PCSK9, ANGPTL3 and lipoprotein (a) in cancers.<h4>Objective/purpose</h4>To compare circulating levels of PCSK9, ANGPTL3, and Lp(a) in women with stage III breast cancer versus women with premalignant or benign breast lesions.<h4>Methods</h4>Twenty-three plasma samples from women diagnosed with a stage III breast cancer (ductal, lobular or mixed) were matched for age with twenty-three plasma samples from women bearing premalignant (stage 0, n = 9) or benign (n","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T21:52:41.372Z","creation":"2025-02-19T01:27:52.25Z"},"accession":"S-EPMC9535963","cross_references":{"pubmed":["36203122"],"doi":["10.1186/s12885-022-10120-6"]}}