biostudies-literatureUnknown42(10)Kern KCPost-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. Patients with stroke or TIA enrolled in a prospective cohort study were included if they had 1) at least one DTI acquisition at acute presentation, 24 hours, 5 days, or 30 days, and 2) follow-up testing with the telephone Montreal Cognitive Assessment (T-MoCA) at 30 and/or 90 days. A whole brain, white-matter skeleton excluding the infarct was used to derive mean global DTI measures for mean diffusivity (MD), fractional anisotropy (FA), free water (FW), FW-corrected MD (MD_tissue), and FW-corrected FA (FA_tissue). In 74 patientJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism1854-1866https://www.ebi.ac.uk/biostudies/studies/S-EPMC9536124biostudies-literatureGlobal changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.PMC9536124Kern KCLeigh RWright CBfalseGlobal changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.Post-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. Patients with stroke or TIA enrolled in a prospective cohort study were included if they had 1) at least one DTI acquisition at acute presentation, 24 hours, 5 days, or 30 days, and 2) follow-up testing with the telephone Montreal Cognitive Assessment (T-MoCA) at 30 and/or 90 days. A whole brain, white-matter skeleton excluding the infarct was used to derive mean global DTI measures for mean diffusivity (MD), fractional anisotropy (FA), free water (FW), FW-corrected MD (MD_tissue), and FW-corrected FA (FA_tissue). In 74 patient2022-01-01T00:00:00Z2022 Oct2026-07-14T16:58:53.892Z2025-04-04T03:42:46.61ZS-EPMC95361243557923610.1177/0271678x22110164410.1177/0271678X221101644