{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vitalle J"],"funding":["Instituto de Salud Carlos III","Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía","Consejería de Salud, Junta de Andalucía"],"pagination":["e161045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9536264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(17)"],"pubmed_abstract":["The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-y"],"journal":["JCI insight"],"pubmed_title":["Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people."],"pmcid":["PMC9536264"],"funding_grant_id":["DOC-00963","CV20-85418","FI19/00083","DOC-01659","PI19/01127","RH-0037-2020","CM20/00243","CP19/00159","FI17/00186","P20_00906"],"pubmed_authors":["Rafii-El-Idrissi Benhnia M","Rivas-Jeremias I","Ruiz-Mateos E","Martin-Sanchez MA","Bachiller S","Silva-Sanchez MDM","Lopez-Cortes LF","Vitalle J","Gasca-Capote C","Jimenez-Leon MR","Ostos FJ","Ruiz-Mateos AM","Perez-Gomez A"],"additional_accession":[]},"is_claimable":false,"name":"Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.","description":"The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-y","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-18T20:59:50.15Z","creation":"2025-04-07T08:59:00.699Z"},"accession":"S-EPMC9536264","cross_references":{"pubmed":["35943812"],"doi":["10.1172/jci.insight.161045"]}}