biostudies-literatureVitalle JInstituto de Salud Carlos IIIConsejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de AndalucíaConsejería de Salud, Junta de Andalucíae161045https://www.ebi.ac.uk/biostudies/studies/S-EPMC9536264biostudies-literatureUnknown7(17)The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-yJCI insightImmune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.PMC9536264DOC-00963CV20-85418FI19/00083DOC-01659PI19/01127RH-0037-2020CM20/00243CP19/00159FI17/00186P20_00906Rafii-El-Idrissi Benhnia MRivas-Jeremias IRuiz-Mateos EMartin-Sanchez MABachiller SSilva-Sanchez MDMLopez-Cortes LFVitalle JGasca-Capote CJimenez-Leon MROstos FJRuiz-Mateos AMPerez-Gomez AfalseImmune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-y2022-01-01T00:00:00Z2022 Sep2025-04-18T20:59:50.15Z2025-04-07T08:59:00.699ZS-EPMC95362643594381210.1172/jci.insight.161045