{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dean T"],"funding":["NICHD NIH HHS","HHS | NIH | National Institute of Neurological Disorders and Stroke","HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","NINDS NIH HHS","DC-IDDRC"],"pagination":["ENEURO.0110-22.2022"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9536852"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["The molecular circadian clock can be found throughout the body and is essential for the synchronizing cellular physiology with the 24 h day. However, the role of the clock in regulating the regenerative potential of the brain has not been explored. We report here that murine NG2-glia, the largest population of proliferative cells in the mature central nervous system, rhythmically express circadian clock genes in a 24 h period, including the critical clock component <i>Bmal1</i> RNA and BMAL1 protein. Interestingly, daily NG2-glia proliferation preferentially occurs during the time of day in which <i>Bmal1</i> expression is high, while conditional knockout of <i>Bmal1</i> decreases both cortical NG2-glia density and cellular proliferation. Furthermore, in a neurotrauma model, we show that p"],"journal":["eNeuro"],"pubmed_title":["Endogenous Circadian Clock Machinery in Cortical NG2-Glia Regulates Cellular Proliferation."],"pmcid":["PMC9536852"],"funding_grant_id":["R37NS109478","P50 HD105328","R37 NS109478","DC-IDDRC U54HD090257 and P50HD105328","K12HD001399","U54 HD090257","K12 HD001399"],"pubmed_authors":["Dean T","Koffi AV","Goldstein E","Ghaemmaghami J","Gallo V"],"additional_accession":[]},"is_claimable":false,"name":"Endogenous Circadian Clock Machinery in Cortical NG2-Glia Regulates Cellular Proliferation.","description":"The molecular circadian clock can be found throughout the body and is essential for the synchronizing cellular physiology with the 24 h day. However, the role of the clock in regulating the regenerative potential of the brain has not been explored. We report here that murine NG2-glia, the largest population of proliferative cells in the mature central nervous system, rhythmically express circadian clock genes in a 24 h period, including the critical clock component <i>Bmal1</i> RNA and BMAL1 protein. Interestingly, daily NG2-glia proliferation preferentially occurs during the time of day in which <i>Bmal1</i> expression is high, while conditional knockout of <i>Bmal1</i> decreases both cortical NG2-glia density and cellular proliferation. Furthermore, in a neurotrauma model, we show that p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep-Oct","modification":"2026-06-12T03:24:09.983Z","creation":"2025-02-19T03:22:51.773Z"},"accession":"S-EPMC9536852","cross_references":{"pubmed":["36123116"],"doi":["10.1523/ENEURO.0110-22.2022"]}}