{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barzilay JI"],"funding":["National Institute of Neurological Disorders and Stroke","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Institutes of Health","National Institute on Aging"],"pagination":["1101-1108.e1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9536862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(9)"],"pubmed_abstract":["<h4>Background</h4>It is uncertain if lipids or lipoproteins are associated with osteoporotic fractures. In this study, incident hip fracture risk according to conventional lipid levels and lipoprotein levels and sizes was examined.<h4>Methods</h4>We followed 5832 participants aged ≥65 years from the Cardiovascular Health Study for hip fracture for a mean of 13.5 (SD 5.7) years. Standard enzymatic methods were used to determine lipid levels (ie, high-density lipoprotein-cholesterol [HDL-c], low-density lipoprotein-cholesterol [LDL-c], and triglycerides). Nuclear magnetic resonance spectroscopy was used to measure lipoprotein fractions (ie, very-low-density lipoprotein-particle [VLDL-P], low-density lipoprotein-particle [LDL-P], high-density lipoprotein-particle [HDL-P]) in a subset of 1849 participants.<h4>Results</h4>We documented 755 incident hip fractures among women (1.19 fractures per 100 participant years [95% confidence interval, 1.04, 1.35]) and 197 among men (0.67 fractures per 100 participant years [95% CI, 0.41, 1.10]) over an average follow-up. HDL-c and LDL-c levels had statistically significant nonlinear U-shaped relationships with hip fracture risk (HDL-c, P = .009; LDL-c, P = .02). Triglyceride levels were not significantly associated with hip fracture risk. In fully adjusted conjoint models, higher VLDL-P concentration (hazard ratio [HR] per 1 standard deviation [SD] increment 1.47 [1.13, 1.91] and size [HR per 1 SD increment 1.24 [1.05, 1.46]) and higher high-density lipoprotein particle size (HR per 1 SD increment 1.81 [1.25, 2.62]) were all associated with higher hip fracture risk.<h4>Conclusions</h4>Lipids and lipoproteins are associated with hip fracture risk in older adults. The associations are complex. Mechanistic studies are needed to understand these findings."],"journal":["The American journal of medicine"],"pubmed_title":["The Association of Lipids and Lipoproteins with Hip Fracture Risk: The Cardiovascular Health Study."],"pmcid":["PMC9536862"],"funding_grant_id":["R01AG023629","HHSN268200800007C"],"pubmed_authors":["Robbins JA","Elam RE","Kuller LH","Carbone LD","Mukamal KJ","Buzkova P","Barzilay JI","Sheets K","Cauley JA","Fink HA"],"additional_accession":[]},"is_claimable":false,"name":"The Association of Lipids and Lipoproteins with Hip Fracture Risk: The Cardiovascular Health Study.","description":"<h4>Background</h4>It is uncertain if lipids or lipoproteins are associated with osteoporotic fractures. In this study, incident hip fracture risk according to conventional lipid levels and lipoprotein levels and sizes was examined.<h4>Methods</h4>We followed 5832 participants aged ≥65 years from the Cardiovascular Health Study for hip fracture for a mean of 13.5 (SD 5.7) years. Standard enzymatic methods were used to determine lipid levels (ie, high-density lipoprotein-cholesterol [HDL-c], low-density lipoprotein-cholesterol [LDL-c], and triglycerides). Nuclear magnetic resonance spectroscopy was used to measure lipoprotein fractions (ie, very-low-density lipoprotein-particle [VLDL-P], low-density lipoprotein-particle [LDL-P], high-density lipoprotein-particle [HDL-P]) in a subset of 1849 participants.<h4>Results</h4>We documented 755 incident hip fractures among women (1.19 fractures per 100 participant years [95% confidence interval, 1.04, 1.35]) and 197 among men (0.67 fractures per 100 participant years [95% CI, 0.41, 1.10]) over an average follow-up. HDL-c and LDL-c levels had statistically significant nonlinear U-shaped relationships with hip fracture risk (HDL-c, P = .009; LDL-c, P = .02). Triglyceride levels were not significantly associated with hip fracture risk. In fully adjusted conjoint models, higher VLDL-P concentration (hazard ratio [HR] per 1 standard deviation [SD] increment 1.47 [1.13, 1.91] and size [HR per 1 SD increment 1.24 [1.05, 1.46]) and higher high-density lipoprotein particle size (HR per 1 SD increment 1.81 [1.25, 2.62]) were all associated with higher hip fracture risk.<h4>Conclusions</h4>Lipids and lipoproteins are associated with hip fracture risk in older adults. The associations are complex. Mechanistic studies are needed to understand these findings.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T17:36:51.196Z","creation":"2025-02-19T00:27:47.81Z"},"accession":"S-EPMC9536862","cross_references":{"pubmed":["35679877"],"doi":["10.1016/j.amjmed.2022.05.024"]}}