biostudies-literatureLabusca LRomanian Ministry of Research, Innovation and Digitization, CNCS/CCCDI - UEFISCDIMinistry of Research, Innovation and Digitization CNCS - UEFISCDI16698https://www.ebi.ac.uk/biostudies/studies/S-EPMC9537172biostudies-literatureUnknown12(1)Magnetic nanomaterials are increasingly impacting the field of biology and medicine. Their versatility in terms of shape, structure, composition, coating, and magnetic responsivity make them attractive for drug delivery, cell targeting and imaging. Adipose derived-mesenchymal cells (ASCs) are intensely scrutinized for tissue engineering and regenerative medicine. However, differentiation into musculoskeletal lineages can be challenging. In this paper, we show that uncoated nickel nanowires (Ni NW) partially released from their alumina membrane offer a mechanically-responsive substrate with regular topography that can be used for the delivery of magneto-mechanical stimulation. We have used a tailored protocol for improving ASCs adherence to the substrate, and showed that cells retain their Scientific reportsMagnetic nanowires substrate increases adipose-derived mesenchymal cells osteogenesis.PMC9537172502PED/2020ERANET-EURONANOMED-3-OASIsPN-III-P4-PCE-2021-1081 within PNCDI III (Contract no. 75/2022)Herea DDDragos-Pinzaru OMinuti AEDanceanu CTibu MLupu NLabusca LChiriac HRotarescu CMarian GGhemes AfalseMagnetic nanowires substrate increases adipose-derived mesenchymal cells osteogenesis.Magnetic nanomaterials are increasingly impacting the field of biology and medicine. Their versatility in terms of shape, structure, composition, coating, and magnetic responsivity make them attractive for drug delivery, cell targeting and imaging. Adipose derived-mesenchymal cells (ASCs) are intensely scrutinized for tissue engineering and regenerative medicine. However, differentiation into musculoskeletal lineages can be challenging. In this paper, we show that uncoated nickel nanowires (Ni NW) partially released from their alumina membrane offer a mechanically-responsive substrate with regular topography that can be used for the delivery of magneto-mechanical stimulation. We have used a tailored protocol for improving ASCs adherence to the substrate, and showed that cells retain their 2022-01-01T00:00:00Z2022 Oct2025-04-18T21:01:50.501Z2025-04-07T09:03:06.857ZS-EPMC95371723620290210.1038/s41598-022-21145-z