{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chuang TD"],"funding":["NICHD NIH HHS","National Institutes of Health"],"pagination":["2960-2976"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9537225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(10)"],"pubmed_abstract":["Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions. Recent studies have revealed that SE-lncRNAs play essential roles in tumorigenesis through the regulation of oncogenes. The objective of this study was to elucidate the expression profile of SE-lncRNAs with concurrent assessment of associated mRNAs in leiomyomas and paired myometrium. Arraystar SE-lncRNAs arrays were used to systematically profile the differentially expressed SE-lncRNAs along with the corresponding SE-regulated protein coding genes in eight leiomyomas and paired myometrium. The analysis indicated 7680 SE-lncRNAs were expressed, of which 721 SE-lncRNAs were overexpressed, while 247 SE-lncRNAs were underexpressed by 1.5-fold or great"],"journal":["Reproductive sciences (Thousand Oaks, Calif.)"],"pubmed_title":["Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas."],"pmcid":["PMC9537225"],"funding_grant_id":["HD100529","R03 HD101852","HD101852","R01 HD100529"],"pubmed_authors":["Quintanilla D","Boos D","Chuang TD","Khorram O"],"additional_accession":[]},"is_claimable":false,"name":"Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas.","description":"Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions. Recent studies have revealed that SE-lncRNAs play essential roles in tumorigenesis through the regulation of oncogenes. The objective of this study was to elucidate the expression profile of SE-lncRNAs with concurrent assessment of associated mRNAs in leiomyomas and paired myometrium. Arraystar SE-lncRNAs arrays were used to systematically profile the differentially expressed SE-lncRNAs along with the corresponding SE-regulated protein coding genes in eight leiomyomas and paired myometrium. The analysis indicated 7680 SE-lncRNAs were expressed, of which 721 SE-lncRNAs were overexpressed, while 247 SE-lncRNAs were underexpressed by 1.5-fold or great","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-04-08T10:50:33.956Z","creation":"2025-02-19T04:02:33.633Z"},"accession":"S-EPMC9537225","cross_references":{"pubmed":["35641855"],"doi":["10.1007/s43032-022-00981-4"]}}