biostudies-literatureChuang TDNICHD NIH HHSNational Institutes of Health2960-2976https://www.ebi.ac.uk/biostudies/studies/S-EPMC9537225biostudies-literatureUnknown29(10)Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions. Recent studies have revealed that SE-lncRNAs play essential roles in tumorigenesis through the regulation of oncogenes. The objective of this study was to elucidate the expression profile of SE-lncRNAs with concurrent assessment of associated mRNAs in leiomyomas and paired myometrium. Arraystar SE-lncRNAs arrays were used to systematically profile the differentially expressed SE-lncRNAs along with the corresponding SE-regulated protein coding genes in eight leiomyomas and paired myometrium. The analysis indicated 7680 SE-lncRNAs were expressed, of which 721 SE-lncRNAs were overexpressed, while 247 SE-lncRNAs were underexpressed by 1.5-fold or greatReproductive sciences (Thousand Oaks, Calif.)Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas.PMC9537225HD100529R03 HD101852HD101852R01 HD100529Quintanilla DBoos DChuang TDKhorram OfalseDifferential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas.Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions. Recent studies have revealed that SE-lncRNAs play essential roles in tumorigenesis through the regulation of oncogenes. The objective of this study was to elucidate the expression profile of SE-lncRNAs with concurrent assessment of associated mRNAs in leiomyomas and paired myometrium. Arraystar SE-lncRNAs arrays were used to systematically profile the differentially expressed SE-lncRNAs along with the corresponding SE-regulated protein coding genes in eight leiomyomas and paired myometrium. The analysis indicated 7680 SE-lncRNAs were expressed, of which 721 SE-lncRNAs were overexpressed, while 247 SE-lncRNAs were underexpressed by 1.5-fold or great2022-01-01T00:00:00Z2022 Oct2026-04-08T10:50:33.956Z2025-02-19T04:02:33.633ZS-EPMC95372253564185510.1007/s43032-022-00981-4