biostudies-literatureChen BXuzhou Key R&amp;D ProgrammeSix Talent Peaks Project in Jiangsu Province3268386https://www.ebi.ac.uk/biostudies/studies/S-EPMC9537619biostudies-literatureUnknown2022<h4>Background</h4>Homeobox D (HOXD) genes were associated with cancer pathogenesis. However, the role of HOXD genes in ovarian cancer (OC) and the possible mechanisms involved are unclear. In this study, we analyzed the function and regulatory mechanisms and functions of HOXD genes in OC based on comprehensive bioinformatics analysis.<h4>Methods</h4>Expression of HOXD1/3/4/8/9/10/11/12/13 mRNA was analyzed between OC tissue and normal tissue using ONCOMINE, GEO, and TCGA databases. The relationship between HOXD expression and clinical stage was studied by GEPIA. The Kaplan-Meier plotter was used to analyze prognosis. cBioPortal was used to analyze the mutation and coexpression of HOXDs. GO and KEGG analyses were performed by the DAVID software to predict the function of HOXD coexpression Computational and mathematical methods in medicineMolecular Analysis of Prognosis and Immune Infiltration of Ovarian Cancer Based on Homeobox D Genes.PMC9537619ZYSB20210489LGY202006Wang HHan ZChen BGao CSun JfalseMolecular Analysis of Prognosis and Immune Infiltration of Ovarian Cancer Based on Homeobox D Genes.<h4>Background</h4>Homeobox D (HOXD) genes were associated with cancer pathogenesis. However, the role of HOXD genes in ovarian cancer (OC) and the possible mechanisms involved are unclear. In this study, we analyzed the function and regulatory mechanisms and functions of HOXD genes in OC based on comprehensive bioinformatics analysis.<h4>Methods</h4>Expression of HOXD1/3/4/8/9/10/11/12/13 mRNA was analyzed between OC tissue and normal tissue using ONCOMINE, GEO, and TCGA databases. The relationship between HOXD expression and clinical stage was studied by GEPIA. The Kaplan-Meier plotter was used to analyze prognosis. cBioPortal was used to analyze the mutation and coexpression of HOXDs. GO and KEGG analyses were performed by the DAVID software to predict the function of HOXD coexpression 2022-01-01T00:00:00Z20222026-07-14T15:51:39.254Z2024-11-08T20:51:52.004ZS-EPMC95376193621358010.1155/2022/3268386