biostudies-literatureYoshida Ajapan agency for medical research and developmentJapanese Ministry of Health, Labour, and Welfare204-216https://www.ebi.ac.uk/biostudies/studies/S-EPMC9537703biostudies-literatureUnknown7(3)<h4>Objective</h4>Severe digital ischemia, including digital ulcers and gangrene, is considered rare in patients with antisynthetase antibodies. This study aimed to elucidate the clinical features of antisynthetase-positive patients complicated with digital ulcers and/or gangrene using a systematic literature review and case series in a single-center cohort.<h4>Methods</h4>A systematic literature review was conducted to identify reports describing antisynthetase-positive cases with digital ulcers and/or gangrene. Our cohort of consecutive patients with antisynthetase antibodies was stratified by the history of severe digital ischemia. Demographic and clinical features and outcomes in patients with severe digital ischemia identified in the systematic literature review and our cohort were coJournal of scleroderma and related disordersSevere digital ischemia as an unrecognized manifestation in patients with antisynthetase autoantibodies: Case series and systematic literature review.PMC9537703grant 21ek0109531h0001a research grant for intractable diseasesOkazaki YYoshida AShirai YKuwana MGono TTakeno MfalseSevere digital ischemia as an unrecognized manifestation in patients with antisynthetase autoantibodies: Case series and systematic literature review.<h4>Objective</h4>Severe digital ischemia, including digital ulcers and gangrene, is considered rare in patients with antisynthetase antibodies. This study aimed to elucidate the clinical features of antisynthetase-positive patients complicated with digital ulcers and/or gangrene using a systematic literature review and case series in a single-center cohort.<h4>Methods</h4>A systematic literature review was conducted to identify reports describing antisynthetase-positive cases with digital ulcers and/or gangrene. Our cohort of consecutive patients with antisynthetase antibodies was stratified by the history of severe digital ischemia. Demographic and clinical features and outcomes in patients with severe digital ischemia identified in the systematic literature review and our cohort were co2022-01-01T00:00:00Z2022 Oct2025-04-25T21:32:28.479Z2025-04-06T08:43:14.743ZS-EPMC95377033621120610.1177/23971983221090857