{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Wang H"],"pubmed_abstract":["<h4>Background and objectives</h4>It is currently controversial whether subclinical hyperthyroidism is associated with <i>PRKAR1A</i> gene variants. We describe a man with subclinical hyperthyroidism and a <i>PRKAR1A</i> gene variant who was diagnosed with Carney complex (CNC), and we performed a systematic review of published studies to assess the association between <i>PRKAR1A</i> gene variants and the risk of subclinical hyperthyroidism.<h4>Design and methods</h4>The PubMed, EMBASE, OVID, Science Direct, and gray literature electronic databases were searched for articles published from January 2002 to May 2021 using predefined keywords and inclusion and exclusion criteria. Data on thyroid function from selected studies were extracted and analyzed.<h4>Results</h4>We identified a CNC pati"],"journal":["Frontiers in endocrinology"],"pagination":["951133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9538310"],"repository":["biostudies-literature"],"pubmed_title":["Association between subclinical hyperthyroidism and a <i>PRKAR1A</i> gene variant in Carney complex patients: A case report and systematic review."],"pmcid":["PMC9538310"],"pubmed_authors":["Mao M","Duan L","Wang H","Liu D"],"additional_accession":[]},"is_claimable":false,"name":"Association between subclinical hyperthyroidism and a <i>PRKAR1A</i> gene variant in Carney complex patients: A case report and systematic review.","description":"<h4>Background and objectives</h4>It is currently controversial whether subclinical hyperthyroidism is associated with <i>PRKAR1A</i> gene variants. We describe a man with subclinical hyperthyroidism and a <i>PRKAR1A</i> gene variant who was diagnosed with Carney complex (CNC), and we performed a systematic review of published studies to assess the association between <i>PRKAR1A</i> gene variants and the risk of subclinical hyperthyroidism.<h4>Design and methods</h4>The PubMed, EMBASE, OVID, Science Direct, and gray literature electronic databases were searched for articles published from January 2002 to May 2021 using predefined keywords and inclusion and exclusion criteria. Data on thyroid function from selected studies were extracted and analyzed.<h4>Results</h4>We identified a CNC pati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T17:33:37.91Z","creation":"2025-04-06T05:18:00.699Z"},"accession":"S-EPMC9538310","cross_references":{"pubmed":["36213268"],"doi":["10.3389/fendo.2022.951133"]}}