biostudies-literatureUnknownRajput RVPatients with severe aplastic anaemia (SAA) are often not vaccinated against viruses due to concerns of ineffective protective antibody response and potential for pathogenic global immune system activation, leading to relapse. We evaluated the impact of COVID-19 vaccination on haematological indices and disease status and characterized the humoural and cellular responses to vaccination in 50 SAA patients, who were previously treated with immunosuppressive therapy (IST). There was no significant difference in haemoglobin (p = 0.52), platelet count (p = 0.67), absolute lymphocyte (p = 0.42) and neutrophil (p = 0.98) counts prior to and after completion of vaccination series. Relapse after vaccination, defined as a progressive decline in counts requiring treatment, occurred in three patients British journal of haematologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9538485biostudies-literatureClinical outcomes and immune responses to SARS-CoV-2 vaccination in severe aplastic anaemia.PMC9538485Novik LGordon IMa XGroarke EMBoswell KLNarpala SRLotter JNaisan MKoup RAJean-Baptiste NRios OJPrabhakaran MWang JLDarden ISerebryannyy LWillis JRajput RVYoung NSWu COMcDermott AGaudinski MMoore CPatel BASuperata JLin BCTrost JCarroll RfalseClinical outcomes and immune responses to SARS-CoV-2 vaccination in severe aplastic anaemia.Patients with severe aplastic anaemia (SAA) are often not vaccinated against viruses due to concerns of ineffective protective antibody response and potential for pathogenic global immune system activation, leading to relapse. We evaluated the impact of COVID-19 vaccination on haematological indices and disease status and characterized the humoural and cellular responses to vaccination in 50 SAA patients, who were previously treated with immunosuppressive therapy (IST). There was no significant difference in haemoglobin (p = 0.52), platelet count (p = 0.67), absolute lymphocyte (p = 0.42) and neutrophil (p = 0.98) counts prior to and after completion of vaccination series. Relapse after vaccination, defined as a progressive decline in counts requiring treatment, occurred in three patients 2022-01-01T00:00:00Z2022 Sep2025-04-21T16:48:21.962Z2025-04-05T11:38:38.197ZS-EPMC95384853612890910.1111/bjh.18456