biostudies-literatureUnknown97(11)Maira DCoronavirus Disease (COVID-19) can be considered as a human pathological model of inflammation combined with hypoxia. In this setting, both erythropoiesis and iron metabolism appear to be profoundly affected by inflammatory and hypoxic stimuli, which act in the opposite direction on hepcidin regulation. The impact of low blood oxygen levels on erythropoiesis and iron metabolism in the context of human hypoxic disease (e.g., pneumonia) has not been fully elucidated. This multicentric observational study was aimed at investigating the prevalence of anemia, the alterations of iron homeostasis, and the relationship between inflammation, hypoxia, and erythropoietic parameters in a cohort of 481 COVID-19 patients admitted both to medical wards and intensive care units (ICU). Data were collected American journal of hematology1404-1412https://www.ebi.ac.uk/biostudies/studies/S-EPMC9538950biostudies-literatureThe role of hypoxia and inflammation in the regulation of iron metabolism and erythropoiesis in COVID-19: The IRONCOVID study.PMC9538950Blasi FCassinerio EGrasselli GBaldini IMValenti LPeyvandi FMaira DMotta IDi Pierro EBandera ADuca LGraziadei GLombardi RMonzani VAliberti SSandri MProietti MGirelli DGuzzardella AFracanzani ALMontano NMarchi GCappellini MDVianello AConsonni DMilani ABusti FSalvatici MCesari MProtti AfalseThe role of hypoxia and inflammation in the regulation of iron metabolism and erythropoiesis in COVID-19: The IRONCOVID study.Coronavirus Disease (COVID-19) can be considered as a human pathological model of inflammation combined with hypoxia. In this setting, both erythropoiesis and iron metabolism appear to be profoundly affected by inflammatory and hypoxic stimuli, which act in the opposite direction on hepcidin regulation. The impact of low blood oxygen levels on erythropoiesis and iron metabolism in the context of human hypoxic disease (e.g., pneumonia) has not been fully elucidated. This multicentric observational study was aimed at investigating the prevalence of anemia, the alterations of iron homeostasis, and the relationship between inflammation, hypoxia, and erythropoietic parameters in a cohort of 481 COVID-19 patients admitted both to medical wards and intensive care units (ICU). Data were collected 2022-01-01T00:00:00Z2022 Nov2025-04-29T11:01:58.094Z2025-04-06T19:47:26.769ZS-EPMC95389503621566710.1002/ajh.26679