biostudies-literatureQuinn KLDepartment of Medicine, University of TorontoNovo Nordisk FondenUniversity of Toronto793-802https://www.ebi.ac.uk/biostudies/studies/S-EPMC9539016biostudies-literatureUnknown17(10)<h4>Background</h4>There is wide variation in mortality among patients hospitalized with COVID-19. Whether this is related to patient or hospital factors is unknown.<h4>Objective</h4>To compare the risk of mortality for patients hospitalized with COVID-19 and to determine whether the majority of that variation was explained by differences in patient characteristics across sites.<h4>Design, setting, and participants</h4>An international multicenter cohort study of hospitalized adults with laboratory-confirmed COVID-19 enrolled from 10 hospitals in Ontario, Canada and 8 hospitals in Copenhagen, Denmark between January 1, 2020 and November 11, 2020.<h4>Main outcomes and measures</h4>Inpatient mortality. We used a multivariable multilevel regression model to compare the in-hospital mortality rJournal of hospital medicineVariation in the risk of death due to COVID-19: An international multicenter cohort study of hospitalized adults.PMC9539016NNF20SA0062835MacFadden DRWeagle RColacci MSkaarup KGZipursky JCressman ABeaman ABartsch EStall NCOVID-ACE GroupLassen MHPerkins BQuinn KLBarrett KMaqbool ATang TWarkentin MTLoukiantchenko SCaruso ARaissi AKhaykin YLapointe-Shaw LBogler OPearson AKandel CGosset ADetsky ALovblom ESegura DRymaszewski KAbdel-Qadir HRothman KJBiering-Sorensen TBarbosa DFralick MYarnell CfalseVariation in the risk of death due to COVID-19: An international multicenter cohort study of hospitalized adults.<h4>Background</h4>There is wide variation in mortality among patients hospitalized with COVID-19. Whether this is related to patient or hospital factors is unknown.<h4>Objective</h4>To compare the risk of mortality for patients hospitalized with COVID-19 and to determine whether the majority of that variation was explained by differences in patient characteristics across sites.<h4>Design, setting, and participants</h4>An international multicenter cohort study of hospitalized adults with laboratory-confirmed COVID-19 enrolled from 10 hospitals in Ontario, Canada and 8 hospitals in Copenhagen, Denmark between January 1, 2020 and November 11, 2020.<h4>Main outcomes and measures</h4>Inpatient mortality. We used a multivariable multilevel regression model to compare the in-hospital mortality r2022-01-01T00:00:00Z2022 Oct2025-04-04T23:20:15.66Z2025-04-04T23:20:15.66ZS-EPMC95390163604011110.1002/jhm.12946