{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Fernandes de Oliveira Costa A"],"pubmed_abstract":["In cancer, tumor cells and their neoplastic microenvironment can sculpt the immunogenic phenotype of a developing tumor. In this context, natural killer (NK) cells are subtypes of lymphocytes of the innate immune system recognized for their potential to eliminate neoplastic cells, not only through direct cytolytic activity but also by favoring the development of an adaptive antitumor immune response. Even though the protective effect against leukemia due to NK-cell alloreactivity mediated by the absence of the KIR-ligand has already been shown, and some data on the role of NK cells in myeloproliferative neoplasms (MPN) has been explored, their mechanisms of immune escape have not been fully investigated. It is still unclear whether NK cells can affect the biology of BCR-ABL1-negative MPN a"],"journal":["Frontiers in immunology"],"pagination":["768592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9539129"],"repository":["biostudies-literature"],"pubmed_title":["Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms."],"pmcid":["PMC9539129"],"pubmed_authors":["Aparecida Lopes I","Agostinho Machado-Neto J","Santos Scheucher P","Samuel Welner R","Kobayashi SS","Lobo de Figueiredo-Pontes L","Carvalho Palma L","Lilian Dos Santos Schiavinato J","Antonio Pereira-Martins D","Magalhaes Rego E","Olops Marani L","Mantello Bianco T","Fernandes de Oliveira Costa A","Sarri Binelli L","Araujo Silva C","Queiroz Arantes A"],"additional_accession":[]},"is_claimable":false,"name":"Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms.","description":"In cancer, tumor cells and their neoplastic microenvironment can sculpt the immunogenic phenotype of a developing tumor. In this context, natural killer (NK) cells are subtypes of lymphocytes of the innate immune system recognized for their potential to eliminate neoplastic cells, not only through direct cytolytic activity but also by favoring the development of an adaptive antitumor immune response. Even though the protective effect against leukemia due to NK-cell alloreactivity mediated by the absence of the KIR-ligand has already been shown, and some data on the role of NK cells in myeloproliferative neoplasms (MPN) has been explored, their mechanisms of immune escape have not been fully investigated. It is still unclear whether NK cells can affect the biology of BCR-ABL1-negative MPN a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T17:28:35.748Z","creation":"2025-04-06T05:10:42.21Z"},"accession":"S-EPMC9539129","cross_references":{"pubmed":["36211444"],"doi":["10.3389/fimmu.2022.768592"]}}