{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Helwer R"],"pubmed_abstract":["RNA helicases are involved in nearly all aspects of RNA metabolism and factor prominently in ribosome assembly. The SSU processome includes 10 helicases and many helicase-cofactors. Together, they mediate the structural rearrangements that occur as part of ribosomal SSU assembly. During the identification of the SSU processome component Utp25/Def, it was noticed that the protein displays some sequence similarity to DEAD-box RNA helicases and is essential for growth. Interestingly, mutational ablation showed that Utp25's DEAD-box motifs are dispensable. Here, we show that the Utp25 AlphaFold prediction displays considerable structural similarity to DEAD-box helicases and is the first fully validated pseudohelicase."],"journal":["microPublication biology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9539457"],"repository":["biostudies-literature"],"pubmed_title":["The SSU Processome Component Utp25p is a Pseudohelicase."],"pmcid":["PMC9539457"],"pubmed_authors":["Charette JM","Helwer R"],"additional_accession":[]},"is_claimable":false,"name":"The SSU Processome Component Utp25p is a Pseudohelicase.","description":"RNA helicases are involved in nearly all aspects of RNA metabolism and factor prominently in ribosome assembly. The SSU processome includes 10 helicases and many helicase-cofactors. Together, they mediate the structural rearrangements that occur as part of ribosomal SSU assembly. During the identification of the SSU processome component Utp25/Def, it was noticed that the protein displays some sequence similarity to DEAD-box RNA helicases and is essential for growth. Interestingly, mutational ablation showed that Utp25's DEAD-box motifs are dispensable. Here, we show that the Utp25 AlphaFold prediction displays considerable structural similarity to DEAD-box helicases and is the first fully validated pseudohelicase.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-29T16:10:29.803Z","creation":"2025-04-05T12:17:27.399Z"},"accession":"S-EPMC9539457","cross_references":{"pubmed":["36212518"],"doi":["10.17912/micropub.biology.000606"]}}