{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["97(8)"],"submitter":["Osunkwo I"],"funding":["Novartis Pharmaceuticals Corporation"],"pubmed_abstract":["The international Sickle Cell World Assessment Survey (SWAY) reported a high impact of sickle cell disease (SCD) on patients' daily lives globally. In this study, we analyzed whether the reported burden differed between patients from the USA (n = 384) and other high-income (HI; n = 820) or low- to middle-income (LMI; n = 941) countries. We assessed symptoms and complications, incidence/management of vaso-occlusive crises (VOCs), treatment utilization/satisfaction, and the impact of SCD on education/employment. Certain symptoms (bone aches, insomnia, and joint stiffness) and complications (swollen/painful fingers/toes, gallstones, vision problems, blood clots, and asthma) were reported proportionally more by patients in the USA than in the HI/LMI countries. Self-reported VOCs were more comm"],"journal":["American journal of hematology"],"pagination":["1055-1064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9540420"],"repository":["biostudies-literature"],"pubmed_title":["Burden of disease, treatment utilization, and the impact on education and employment in patients with sickle cell disease: A comparative analysis of high- and low- to middle-income countries for the international Sickle Cell World Assessment Survey."],"pmcid":["PMC9540420"],"pubmed_authors":["Osunkwo I","Trimnell C","Bailey T","El-Rassi F","Paulose J","Nero A","James J","Minniti CP","Andemariam B","Ramscar N","Rajkovic-Hooley O"],"additional_accession":[]},"is_claimable":false,"name":"Burden of disease, treatment utilization, and the impact on education and employment in patients with sickle cell disease: A comparative analysis of high- and low- to middle-income countries for the international Sickle Cell World Assessment Survey.","description":"The international Sickle Cell World Assessment Survey (SWAY) reported a high impact of sickle cell disease (SCD) on patients' daily lives globally. In this study, we analyzed whether the reported burden differed between patients from the USA (n = 384) and other high-income (HI; n = 820) or low- to middle-income (LMI; n = 941) countries. We assessed symptoms and complications, incidence/management of vaso-occlusive crises (VOCs), treatment utilization/satisfaction, and the impact of SCD on education/employment. Certain symptoms (bone aches, insomnia, and joint stiffness) and complications (swollen/painful fingers/toes, gallstones, vision problems, blood clots, and asthma) were reported proportionally more by patients in the USA than in the HI/LMI countries. Self-reported VOCs were more comm","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-22T12:10:52.504Z","creation":"2025-04-06T00:13:11.958Z"},"accession":"S-EPMC9540420","cross_references":{"pubmed":["35472249"],"doi":["10.1002/ajh.26576"]}}