{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mercier MS"],"funding":["Epilepsy Research UK","Epilepsy Research Institute UK","Medical Research Council","Rosetrees","Wellcome Trust"],"pagination":["4001-4017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9540908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["600(17)"],"pubmed_abstract":["Apical dendrites of pyramidal neurons integrate information from higher-order cortex and thalamus, and gate signalling and plasticity at proximal synapses. In the hippocampus, neurogliaform cells and other interneurons located within stratum lacunosum-moleculare (SLM) mediate powerful inhibition of CA1 pyramidal neuron distal dendrites. Is the recruitment of such inhibition itself subject to use-dependent plasticity, and if so, what induction rules apply? Here we show that interneurons in mouse SLM exhibit Hebbian NMDA receptor-dependent long-term potentiation (LTP). Such plasticity can be induced by selective optogenetic stimulation of afferents in the temporoammonic pathway from the entorhinal cortex (EC), but not by equivalent stimulation of afferents from the thalamic nucleus reuniens."],"journal":["The Journal of physiology"],"pubmed_title":["Long-term potentiation in neurogliaform interneurons modulates excitation-inhibition balance in the temporoammonic pathway."],"pmcid":["PMC9540908"],"funding_grant_id":["P1702","Seedcorn2021 100113","MR/W005204/1","MR/L01095X/1","MR/V034758/1","212285/Z/18/Z","F1901","209807/Z/17/Z","MR/V013556/1"],"pubmed_authors":["Kullmann DM","Magloire V","Cornford JH","Mercier MS"],"additional_accession":[]},"is_claimable":false,"name":"Long-term potentiation in neurogliaform interneurons modulates excitation-inhibition balance in the temporoammonic pathway.","description":"Apical dendrites of pyramidal neurons integrate information from higher-order cortex and thalamus, and gate signalling and plasticity at proximal synapses. In the hippocampus, neurogliaform cells and other interneurons located within stratum lacunosum-moleculare (SLM) mediate powerful inhibition of CA1 pyramidal neuron distal dendrites. Is the recruitment of such inhibition itself subject to use-dependent plasticity, and if so, what induction rules apply? Here we show that interneurons in mouse SLM exhibit Hebbian NMDA receptor-dependent long-term potentiation (LTP). Such plasticity can be induced by selective optogenetic stimulation of afferents in the temporoammonic pathway from the entorhinal cortex (EC), but not by equivalent stimulation of afferents from the thalamic nucleus reuniens.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-07-14T15:55:13.936Z","creation":"2025-04-04T09:29:56.537Z"},"accession":"S-EPMC9540908","cross_references":{"pubmed":["35876215"],"doi":["10.1113/JP282753"]}}