biostudies-literatureSheppard KWNational Center for Advancing Translational SciencesCures Within ReachNCATS NIH HHSThe Marci and Bill Ingram Fund for Autism Spectrum Disorders Research3358-3369https://www.ebi.ac.uk/biostudies/studies/S-EPMC9540981biostudies-literatureUnknown47(11)Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD.Journal of autism and developmental disordersEffect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms.PMC9540981UL1TR001070UL1 TR001070Gracious BKeim SARogers LKKlebanoff MASheppard KWRausch JBartlett CBoone KMCoury DLfalseEffect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms.Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD.2017-01-01T00:00:00Z2017 Nov2026-05-31T16:06:06.411Z2025-02-19T01:27:50.22ZS-EPMC95409812874833410.1007/s10803-017-3249-3