{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paolino M"],"funding":["Labex NIE","EUR QMAT","CNRS and Inserm","FRI STRAT'US","Interdisciplinary Thematic Institute Qmat"],"pagination":["e202201477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9541190"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(50)"],"pubmed_abstract":["HBDI-like chromophores represent a novel set of biomimetic switches mimicking the fluorophore of the green fluorescent protein that are currently studied with the hope to expand the molecular switch/motor toolbox. However, until now members capable of absorbing visible light in their neutral (i. e. non-anionic) form have not been reported. In this contribution we report the preparation of an HBDI-like chromophore based on a 3-phenylbenzofulvene scaffold capable of absorbing blue light and photoisomerizing on the picosecond timescale. More specifically, we show that double-bond photoisomerization occurs in both the E-to-Z and Z-to-E directions and that these can be controlled by irradiating with blue and UV light, respectively. Finally, as a preliminary applicative result, we report the inc"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Design, Synthesis and Characterization of a Visible-Light-Sensitive Molecular Switch and Its PEGylation Towards a Self-Assembling Molecule."],"pmcid":["PMC9541190"],"funding_grant_id":["ANR-17-EURE-002","TI 2021-2028","ANR-11-LABX-0058_NIE","ANR 10 IDEX 0002","ANR 20 SFRI 0012"],"pubmed_authors":["Gentile M","Cappelli A","Giuliani G","Marquette A","Carlotti B","Paolino M","Olivucci M","Reale A","Varvara P","Giorgi G","Donati A","Bonechi C","Latterini L","Licciardi M","Ortica F","Leonard J","Saletti M","Paccagnini E"],"additional_accession":[]},"is_claimable":false,"name":"Design, Synthesis and Characterization of a Visible-Light-Sensitive Molecular Switch and Its PEGylation Towards a Self-Assembling Molecule.","description":"HBDI-like chromophores represent a novel set of biomimetic switches mimicking the fluorophore of the green fluorescent protein that are currently studied with the hope to expand the molecular switch/motor toolbox. However, until now members capable of absorbing visible light in their neutral (i. e. non-anionic) form have not been reported. In this contribution we report the preparation of an HBDI-like chromophore based on a 3-phenylbenzofulvene scaffold capable of absorbing blue light and photoisomerizing on the picosecond timescale. More specifically, we show that double-bond photoisomerization occurs in both the E-to-Z and Z-to-E directions and that these can be controlled by irradiating with blue and UV light, respectively. Finally, as a preliminary applicative result, we report the inc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T20:04:10.178Z","creation":"2025-04-04T20:04:10.178Z"},"accession":"S-EPMC9541190","cross_references":{"pubmed":["35695822"],"doi":["10.1002/chem.202201477"]}}