{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Monasso GS"],"funding":["European Research Council","ZonMw","Erasmus Medisch Centrum"],"pagination":["e12926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9541379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(10)"],"pubmed_abstract":["<h4>Background</h4>Body mass index is associated with carotid intima-media thickness and distensibility in adults and children.<h4>Objective</h4>To examine whether general and specific fat depots are associated with these markers of arterial health at school age.<h4>Methods</h4>This cross-sectional analysis was embedded in a population-based prospective cohort study among 4708 children aged 10 years. Body, lean and fat mass index were estimated by dual-energy X-ray absorptiometry. Pericardial, visceral and liver fat were estimated by magnetic resonance imaging. Carotid intima-media thickness and distensibility were measured by ultrasound.<h4>Results</h4>A 1-standard-deviation-score (SDS) higher body mass index was associated with higher carotid intima-media thickness (0.06 SDS, 95% confidence interval [CI]: 0.03-0.08) and lower distensibility (-0.17 SDS, 95% CI: -0.20 to -0.14). These associations tended to be similar for lean mass index. A 1-SDS higher fat mass index was associated with lower carotid intima-media thickness (-0.08 SDS, 95% CI: -0.11 to -0.05) and lower distensibility (-0.10 SDS, 95% CI: -0.14 to -0.07). A 1-SDS higher liver fat fraction was associated with lower carotid intima-media thickness (-0.04 SDS, 95% CI: -0.08 to -0.00) and lower distensibility (-0.06 SDS, 95% CI: -0.10 to -0.03). We observed similar associations for visceral fat.<h4>Conclusions</h4>At school age, lean and fat mass seem to be differentially related to carotid intima-media thickness but not distensibility. Arterial development might be affected by lean mass, general and specific fat mass."],"journal":["Pediatric obesity"],"pubmed_title":["Body fat, pericardial fat, liver fat and arterial health at age 10 years."],"pmcid":["PMC9541379"],"funding_grant_id":["543003109","ERC‐2014‐CoG‐648916"],"pubmed_authors":["Oei E","Felix JF","Santos S","Jaddoe VWV","Gaillard R","Monasso GS","Silva CCV","Geurtsen ML"],"additional_accession":[]},"is_claimable":false,"name":"Body fat, pericardial fat, liver fat and arterial health at age 10 years.","description":"<h4>Background</h4>Body mass index is associated with carotid intima-media thickness and distensibility in adults and children.<h4>Objective</h4>To examine whether general and specific fat depots are associated with these markers of arterial health at school age.<h4>Methods</h4>This cross-sectional analysis was embedded in a population-based prospective cohort study among 4708 children aged 10 years. Body, lean and fat mass index were estimated by dual-energy X-ray absorptiometry. Pericardial, visceral and liver fat were estimated by magnetic resonance imaging. Carotid intima-media thickness and distensibility were measured by ultrasound.<h4>Results</h4>A 1-standard-deviation-score (SDS) higher body mass index was associated with higher carotid intima-media thickness (0.06 SDS, 95% confidence interval [CI]: 0.03-0.08) and lower distensibility (-0.17 SDS, 95% CI: -0.20 to -0.14). These associations tended to be similar for lean mass index. A 1-SDS higher fat mass index was associated with lower carotid intima-media thickness (-0.08 SDS, 95% CI: -0.11 to -0.05) and lower distensibility (-0.10 SDS, 95% CI: -0.14 to -0.07). A 1-SDS higher liver fat fraction was associated with lower carotid intima-media thickness (-0.04 SDS, 95% CI: -0.08 to -0.00) and lower distensibility (-0.06 SDS, 95% CI: -0.10 to -0.03). We observed similar associations for visceral fat.<h4>Conclusions</h4>At school age, lean and fat mass seem to be differentially related to carotid intima-media thickness but not distensibility. Arterial development might be affected by lean mass, general and specific fat mass.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T01:57:45.24Z","creation":"2025-04-05T20:09:56.212Z"},"accession":"S-EPMC9541379","cross_references":{"pubmed":["35509243"],"doi":["10.1111/ijpo.12926"]}}