biostudies-literatureLee HJMinistry of Science and TechnologyChang Gung Medical Foundatione13838https://www.ebi.ac.uk/biostudies/studies/S-EPMC9541746biostudies-literatureUnknown33(8)<h4>Background</h4>Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic diseases in Asian children.<h4>Methods</h4>Five hundred and sixty-six Asian children with valid cord blood IgE measurements at birth participated a 6-year follow-up visit including a questionnaire, serum total and allergen-specific IgE, FeNO measurement, and spirometry. Regression-based analyses with covariates adjustment were applied.<h4>Results</h4>Cord blood IgE levels were significantPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyCord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren.PMC9541746CMRPG3J0161~3MOST 107‐2314‐B‐400‐031‐MY3MOST 109‐2314‐B‐182‐042‐MY3CMRPG3K1371~2CMRPG3F1711~3CMRPG3J0121~3Gau CCYao TCTsai HJHuang JLHuang HYHo CHLee HJfalseCord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren.<h4>Background</h4>Few data are available in Asian children regarding the validity of cord blood immunoglobulin E (IgE) in predicting allergic sensitization and pulmonary function. The relationship between cord blood IgE and fraction of exhaled nitric oxide (FeNO) remains unknown. This study investigated the associations of cord blood IgE with allergic sensitization, FeNO, pulmonary function, and allergic diseases in Asian children.<h4>Methods</h4>Five hundred and sixty-six Asian children with valid cord blood IgE measurements at birth participated a 6-year follow-up visit including a questionnaire, serum total and allergen-specific IgE, FeNO measurement, and spirometry. Regression-based analyses with covariates adjustment were applied.<h4>Results</h4>Cord blood IgE levels were significant2022-01-01T00:00:00Z2022 Aug2025-04-22T12:07:04.385Z2025-04-06T00:14:44.694ZS-EPMC95417463600304810.1111/pai.13838