biostudies-literatureMegyesfalvi ZAustrian Science Fund FWFSemmelweis EgyetemMagyar Tüdőgyógyász TársaságInnovációs és Technológiai MinisztériumMagyar Tudományos AkadémiaNemzeti Kutatási Fejlesztési és Innovációs Hivatal674-686https://www.ebi.ac.uk/biostudies/studies/S-EPMC9541929biostudies-literatureUnknown257(5)The tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) present an evolving area of research in small-cell lung cancer (SCLC). The expression of subtype-specific transcription factors and P53 and RB1 proteins were measured by immunohistochemistry (IHC) in 386 surgically resected SCLC samples. Correlations between subtype-specific proteins and in vitro efficacy of various therapeutic agents were investigated by proteomics and cell viability assays in 26 human SCLC cell lines. Besides SCLC-A (ASCL1-dominant), SCLC-AN (combined ASCL1/NEUROD1), SCLC-N (NEUROD1-dominant), and SCLC-P (POU2F3-dominant), IHC and cluster analyses identified a quadruple-negative SCLC subtype (SCLC-QN). No unique YAP1-subtype was found. The highest overall survivalThe Journal of pathologyExpression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study.PMC9541929NAP2‐2017‐1.2.1‐NKP‐00002UNKP‐19‐4OTKA 124652KKP126790FWF I3522UNKP‐20‐3UNKP‐21‐3FWF I3977MPA 2020K129065OTKA129664I4677Bolyai Research ScholarshipTKP2021‐EGA‐33KH130356EFOP‐3.6.3‐VEKOP‐16‐2017‐000092021‐1.1.6‐JOVŐLantos ASzeitz BHirsch FROberndorfer FMarko-Varga GLohinai ZRenyi-Vamos FHoda MALaszlo VKlikovits TLang CKovacevic MBogos KRezeli MBarany NFerencz BValko ZPopper HKern IRivard CPaku SGalffy GSkarda JSchwendenwein ASchelch KMegyesfalvi ZDezso KBrcic LFillinger JMoldvay JPipek OMittak MHoetzenecker KDome BfalseExpression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study.The tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) present an evolving area of research in small-cell lung cancer (SCLC). The expression of subtype-specific transcription factors and P53 and RB1 proteins were measured by immunohistochemistry (IHC) in 386 surgically resected SCLC samples. Correlations between subtype-specific proteins and in vitro efficacy of various therapeutic agents were investigated by proteomics and cell viability assays in 26 human SCLC cell lines. Besides SCLC-A (ASCL1-dominant), SCLC-AN (combined ASCL1/NEUROD1), SCLC-N (NEUROD1-dominant), and SCLC-P (POU2F3-dominant), IHC and cluster analyses identified a quadruple-negative SCLC subtype (SCLC-QN). No unique YAP1-subtype was found. The highest overall survival2022-01-01T00:00:00Z2022 Aug2025-04-22T12:05:58.122Z2025-04-06T00:14:42.049ZS-EPMC95419293548903810.1002/path.5922