{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112(3)"],"submitter":["Cuccaro A"],"pubmed_abstract":["Hodgkin lymphoma (HL) is a neoplastic disease in which the inflammatory microenvironment plays a pivotal role in the tumorigenesis. Neutrophilia is a typical finding in HL at diagnosis and, in particular, in association with lymphocytopenia, is a negative prognostic factor. As the immune checkpoint Programmed Death (PD)-L1/PD-1 has become an important therapeutic target, we were interested in the expression of PD-L1 in peripheral blood (PB) leukocytes using flow cytometry and RT-PCR in patients with HL and healthy controls. Granulocytes were the major PB cell fraction expressing PD-L1. PD-L1 expression on granulocytes was higher in patients with HL than in controls and correlated with lower T-cell numbers in PB. We analyzed for associations between PD-L1 expression in PB granulocytes at th"],"journal":["Journal of leukocyte biology"],"pagination":["539-545"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542012"],"repository":["biostudies-literature"],"pubmed_title":["PD-L1 expression in peripheral blood granulocytes at diagnosis as prognostic factor in classical Hodgkin lymphoma."],"pmcid":["PMC9542012"],"pubmed_authors":["Martini M","Corrente F","Fatone F","Giordano A","Bellesi S","Zangrilli I","De Stefano V","Alma E","Cupelli E","Maiolo E","Annunziata S","Galli E","Rufini V","Larocca LM","Cuccaro A","Viscovo M","D'Alo F","Hohaus S"],"additional_accession":[]},"is_claimable":false,"name":"PD-L1 expression in peripheral blood granulocytes at diagnosis as prognostic factor in classical Hodgkin lymphoma.","description":"Hodgkin lymphoma (HL) is a neoplastic disease in which the inflammatory microenvironment plays a pivotal role in the tumorigenesis. Neutrophilia is a typical finding in HL at diagnosis and, in particular, in association with lymphocytopenia, is a negative prognostic factor. As the immune checkpoint Programmed Death (PD)-L1/PD-1 has become an important therapeutic target, we were interested in the expression of PD-L1 in peripheral blood (PB) leukocytes using flow cytometry and RT-PCR in patients with HL and healthy controls. Granulocytes were the major PB cell fraction expressing PD-L1. PD-L1 expression on granulocytes was higher in patients with HL than in controls and correlated with lower T-cell numbers in PB. We analyzed for associations between PD-L1 expression in PB granulocytes at th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T04:46:37.233Z","creation":"2025-04-19T04:46:37.233Z"},"accession":"S-EPMC9542012","cross_references":{"pubmed":["35060170"],"doi":["10.1002/JLB.5AB0121-041R"]}}