{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(1)"],"submitter":["Najm MAA"],"funding":["the Italian Ministry for University and Research"],"pubmed_abstract":["The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthioureido core were prepared featuring different zinc-binding groups; the conventional sulphamoyl group <b>4a-d</b> and <b>12a-c</b>, its bioisosteric carboxylic acid group <b>5a-d</b> and <b>13a-c</b> or the ethyl carboxylate group <b>6a-d</b> and <b>14a-c</b> as potential prodrugs. All compounds were assessed for their carbonic anhydrase (CA) inhibitory activity against a panel of four physiologically relevant human CA isoforms hCA I and hCA II, and hCA IX, and hCA XII. Compounds <b>4a</b>, <b>4b</b>, <b>4c, 4d, 5d</b>, <b>12a</b>, and <b>12c</b"],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pagination":["2702-2709"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542353"],"repository":["biostudies-literature"],"pubmed_title":["Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes."],"pmcid":["PMC9542353"],"pubmed_authors":["Taher AT","Awadallah FM","Vullo D","Mahmoud WR","Najm MAA","Abbas SE","Allam HA","Supuran CT"],"additional_accession":[]},"is_claimable":false,"name":"Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes.","description":"The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthioureido core were prepared featuring different zinc-binding groups; the conventional sulphamoyl group <b>4a-d</b> and <b>12a-c</b>, its bioisosteric carboxylic acid group <b>5a-d</b> and <b>13a-c</b> or the ethyl carboxylate group <b>6a-d</b> and <b>14a-c</b> as potential prodrugs. All compounds were assessed for their carbonic anhydrase (CA) inhibitory activity against a panel of four physiologically relevant human CA isoforms hCA I and hCA II, and hCA IX, and hCA XII. Compounds <b>4a</b>, <b>4b</b>, <b>4c, 4d, 5d</b>, <b>12a</b>, and <b>12c</b","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-25T17:35:10.416Z","creation":"2025-04-06T05:03:18.212Z"},"accession":"S-EPMC9542353","cross_references":{"pubmed":["36168122"],"doi":["10.1080/14756366.2022.2126463"]}}