biostudies-literatureUnknown33(6)Dahdah LDanone Nutricia Research<h4>Background</h4>Extensively hydrolyzed formulas are recommended for the dietary management of infants with cow's milk allergy (CMA).<h4>Objectives</h4>Hypoallergenicity, growth, and gastrointestinal (GI) tolerability of a new extensively hydrolyzed whey-protein formula (eHWF) in CMA children were assessed.<h4>Methods</h4>In this prospective, randomized, international, multi-center study (Trial NL3889), 34 children with confirmed CMA (74% IgE-mediated) underwent a double-blind, placebo-controlled food challenge (DBPCFC) with an eHWF developed with non-porcine enzymes, supplemented with prebiotic short-chain galacto- and long-chain fructo-oligosaccharides (0.8 g/L, ratio 9:1), arachidonic acid (0.35/100 g), and docosahexaenoic acid (0.35/100 g). If tolerant to the eHWF, children participaPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunologye13814https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542408biostudies-literatureHypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.PMC9542408Rijnierse ABrand PLPFiocchi AKnipping Kde Vries ERoelofs MDahdah LGarssen JfalseHypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.<h4>Background</h4>Extensively hydrolyzed formulas are recommended for the dietary management of infants with cow's milk allergy (CMA).<h4>Objectives</h4>Hypoallergenicity, growth, and gastrointestinal (GI) tolerability of a new extensively hydrolyzed whey-protein formula (eHWF) in CMA children were assessed.<h4>Methods</h4>In this prospective, randomized, international, multi-center study (Trial NL3889), 34 children with confirmed CMA (74% IgE-mediated) underwent a double-blind, placebo-controlled food challenge (DBPCFC) with an eHWF developed with non-porcine enzymes, supplemented with prebiotic short-chain galacto- and long-chain fructo-oligosaccharides (0.8 g/L, ratio 9:1), arachidonic acid (0.35/100 g), and docosahexaenoic acid (0.35/100 g). If tolerant to the eHWF, children participa2022-01-01T00:00:00Z2022 Jun2025-04-22T12:07:59.276Z2025-04-06T00:12:24.264ZS-EPMC95424083575413010.1111/pai.13814