biostudies-literatureUnknown90(9)do Nascimento Soares TConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação Oswaldo CruzFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroKlebsiella pneumoniae is an opportunistic pathogen, which concerns public health systems worldwide, as multiple antibiotic-resistant strains are frequent. One of its pathogenicity factors is the Type VI Secretion System (T6SS), a macromolecular complex assembled through the bacterial membranes. T6SS injects effector proteins inside target cells. Such effectors confer competitive advantages or modulate the target cell signaling and metabolism to favor bacterial infection. The VgrG protein is a T6SS core component. It may present a variable C-terminal domain carrying an additional effector function. Kp52.145 genome encodes three VgrG proteins, one of them with a C-terminal extension (VgrG4-CTD). VgrG4-CTD is 138 amino acids long, does not contain domains of known function, but is conserved iProteins1655-1668https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542434biostudies-literatureThe C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments.PMC9542434Ceneviva Lacerda Almeida FMiranda Santos Lery Ldo Nascimento Soares TBatista PRBerredo-Pinho MSilva Valadares VMascarello Bisch Pde Mattos Lacerda de Carvalho MCardoso Amorim GfalseThe C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments.Klebsiella pneumoniae is an opportunistic pathogen, which concerns public health systems worldwide, as multiple antibiotic-resistant strains are frequent. One of its pathogenicity factors is the Type VI Secretion System (T6SS), a macromolecular complex assembled through the bacterial membranes. T6SS injects effector proteins inside target cells. Such effectors confer competitive advantages or modulate the target cell signaling and metabolism to favor bacterial infection. The VgrG protein is a T6SS core component. It may present a variable C-terminal domain carrying an additional effector function. Kp52.145 genome encodes three VgrG proteins, one of them with a C-terminal extension (VgrG4-CTD). VgrG4-CTD is 138 amino acids long, does not contain domains of known function, but is conserved i2022-01-01T00:00:00Z2022 Sep2026-05-28T04:42:27.44Z2024-11-21T06:46:29.485ZS-EPMC95424343543076710.1002/prot.26344