biostudies-literatureLi HNational Natural Science Foundation of China“Ten thousand plan” innovation leader of Zhejiang Province2127456https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542615biostudies-literatureUnknown14(1)Severe acute pancreatitis (SAP) is a critical illness characterized by a severe systemic inflammatory response resulting in persistent multiple organ failure and sepsis. The intestinal microbiome is increasingly appreciated to play a crucial role in modulation of AP disease outcome, but limited information is available about the identity and mechanism of action for specific commensal bacteria involved in AP-associated inflammation. Here we show that <i>Bifidobacteria</i>, particularly <i>B. animalis</i>, can protect against AP by regulating pancreatic and systemic inflammation in germ-free (GF) and oral antibiotic-treated (Abx) mouse models. Colonization by <i>B. animalis</i> and administration of its metabolite lactate protected Abx and GF mice from AP by reducing serum amylase concentratGut microbes<i>Bifidobacterium</i> spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses.PMC9542615U21A202612020R52007820020733217864Li HYang GLiu JGuo XWang CWang DYue MWang GYu HLiu WCai BZheng HZhu SJGuo JQi XXie JGuo FChen STang Yfalse<i>Bifidobacterium</i> spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses.Severe acute pancreatitis (SAP) is a critical illness characterized by a severe systemic inflammatory response resulting in persistent multiple organ failure and sepsis. The intestinal microbiome is increasingly appreciated to play a crucial role in modulation of AP disease outcome, but limited information is available about the identity and mechanism of action for specific commensal bacteria involved in AP-associated inflammation. Here we show that <i>Bifidobacteria</i>, particularly <i>B. animalis</i>, can protect against AP by regulating pancreatic and systemic inflammation in germ-free (GF) and oral antibiotic-treated (Abx) mouse models. Colonization by <i>B. animalis</i> and administration of its metabolite lactate protected Abx and GF mice from AP by reducing serum amylase concentrat2022-01-01T00:00:00Z2022 Jan-Dec2025-04-04T14:34:28.467Z2025-04-04T14:34:28.467ZS-EPMC95426153619597210.1080/19490976.2022.2127456