{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(10)"],"submitter":["Hugo Silva M"],"pubmed_abstract":["Long-acting injectables are a unique drug formulation strategy, providing a slow and sustained release of active pharmaceutical ingredients (APIs). In this study, a novel approach that combines liquid antisolvent precipitation with seeding to obtain a stable form of the API indomethacin while achieving the desired particle size distribution is described. It was proven that when a metastable form of indomethacin was initially nucleated, the rate of its transformation to the stable form was influenced by the presence of excipients and seeds (17.10 ± 0.20 μm), decreasing from 48 to 4 h. The final particle size (D50) of the indomethacin suspension produced without seeding was 7.33 ± 0.38 μm, and with seeding, it was 5.61 ± 0.14 μm. Additionally, it was shown that the particle size distribution"],"journal":["Crystal growth & design"],"pagination":["6056-6069"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542716"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Excipients and Seeding on the Solid-State Form Transformation of Indomethacin during Liquid Antisolvent Precipitation."],"pmcid":["PMC9542716"],"pubmed_authors":["Holm R","Hudson SP","Hugo Silva M","Tajber L","Kumar A","Hodnett BK"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Excipients and Seeding on the Solid-State Form Transformation of Indomethacin during Liquid Antisolvent Precipitation.","description":"Long-acting injectables are a unique drug formulation strategy, providing a slow and sustained release of active pharmaceutical ingredients (APIs). In this study, a novel approach that combines liquid antisolvent precipitation with seeding to obtain a stable form of the API indomethacin while achieving the desired particle size distribution is described. It was proven that when a metastable form of indomethacin was initially nucleated, the rate of its transformation to the stable form was influenced by the presence of excipients and seeds (17.10 ± 0.20 μm), decreasing from 48 to 4 h. The final particle size (D50) of the indomethacin suspension produced without seeding was 7.33 ± 0.38 μm, and with seeding, it was 5.61 ± 0.14 μm. Additionally, it was shown that the particle size distribution","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-29T11:01:30.138Z","creation":"2025-04-06T19:47:23.765Z"},"accession":"S-EPMC9542716","cross_references":{"pubmed":["36217420"],"doi":["10.1021/acs.cgd.2c00678"]}}