biostudies-literatureUnknown28(19)Sunday JMThe California Current Marine Ecosystem is a highly productive system that exhibits strong natural variability and vulnerability to anthropogenic climate trends. Relating projections of ocean change to biological sensitivities requires detailed synthesis of experimental results. Here, we combine measured biological sensitivities with high-resolution climate projections of key variables (temperature, oxygen, and pCO₂ ) to identify the direction, magnitude, and spatial distribution of organism-scale vulnerabilities to multiple axes of projected ocean change. Among 12 selected species of cultural and economic importance, we find that all are sensitive to projected changes in ocean conditions through responses that affect individual performance or population processes. Response indiGlobal change biology5726-5740https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542873biostudies-literatureBiological sensitivities to high-resolution climate change projections in the California current marine ecosystem.PMC9542873Newton JMacCready PPilcher DJDeutsch CSunday JMKlinger TSiedlecki SHoward EfalseBiological sensitivities to high-resolution climate change projections in the California current marine ecosystem.The California Current Marine Ecosystem is a highly productive system that exhibits strong natural variability and vulnerability to anthropogenic climate trends. Relating projections of ocean change to biological sensitivities requires detailed synthesis of experimental results. Here, we combine measured biological sensitivities with high-resolution climate projections of key variables (temperature, oxygen, and pCO₂ ) to identify the direction, magnitude, and spatial distribution of organism-scale vulnerabilities to multiple axes of projected ocean change. Among 12 selected species of cultural and economic importance, we find that all are sensitive to projected changes in ocean conditions through responses that affect individual performance or population processes. Response indi2022-01-01T00:00:00Z2022 Oct2026-04-12T15:38:20.188Z2025-04-05T20:10:59.763ZS-EPMC95428733589962810.1111/gcb.16317