{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["51(6)"],"submitter":["Idrees M"],"funding":["University of Western Australia","Australian Dental Research Foundation"],"pubmed_abstract":["<h4>Background</h4>This study assessed the efficacy of using oral liquid-based brush cytology (OLBC) coupled with immunostained cytology-derived cell-blocks, quantified using machine-learning, in the diagnosis of oral lichen planus (OLP).<h4>Methods</h4>Eighty-two patients diagnosed clinically with either OLP or oral lichenoid lesion (OLL) were included. OLBC samples were obtained from all patients before undergoing surgical biopsy. Liquid-based cytology slides and cell-blocks were prepared and assessed by cytomorphology and immunocytochemistry for four antibodies (Ki-67, BAX, NF-κB-p65, and AMACR). For comparison purposes, a sub-group of 31 matched surgical biopsy samples were selected randomly and assessed by immunohistochemistry. Patients were categorized according to their definitive d"],"journal":["Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology"],"pagination":["563-572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9542982"],"repository":["biostudies-literature"],"pubmed_title":["Immunoexpression of oral brush biopsy enhances the accuracy of diagnosis for oral lichen planus and lichenoid lesions."],"pmcid":["PMC9542982"],"pubmed_authors":["Kujan O","Shearston K","Idrees M","Farah CS"],"additional_accession":[]},"is_claimable":false,"name":"Immunoexpression of oral brush biopsy enhances the accuracy of diagnosis for oral lichen planus and lichenoid lesions.","description":"<h4>Background</h4>This study assessed the efficacy of using oral liquid-based brush cytology (OLBC) coupled with immunostained cytology-derived cell-blocks, quantified using machine-learning, in the diagnosis of oral lichen planus (OLP).<h4>Methods</h4>Eighty-two patients diagnosed clinically with either OLP or oral lichenoid lesion (OLL) were included. OLBC samples were obtained from all patients before undergoing surgical biopsy. Liquid-based cytology slides and cell-blocks were prepared and assessed by cytomorphology and immunocytochemistry for four antibodies (Ki-67, BAX, NF-κB-p65, and AMACR). For comparison purposes, a sub-group of 31 matched surgical biopsy samples were selected randomly and assessed by immunohistochemistry. Patients were categorized according to their definitive d","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T20:03:47.151Z","creation":"2025-04-04T20:03:47.151Z"},"accession":"S-EPMC9542982","cross_references":{"pubmed":["35460123"],"doi":["10.1111/jop.13301"]}}