{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiao L"],"funding":["Natural Science Foundation of Zhejiang Province","Postdoctoral Research Foundation of China","National Natural Science Foundation of China"],"pagination":["1205-1218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543047"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(10)"],"pubmed_abstract":["Preimplantation development is critical for reproductive successes in mammals. Thus, it is important to understand how preimplantation embryogenesis is regulated. As a key event of preimplantation development, epigenetic reprogramming has been widely studied, yet how epigenetic complexes regulate preimplantation development remains largely unknown. Retinoblastoma binding protein 4 (RBBP4) and 7 (RBBP7) are integral components of epigenetic complexes including SIN3A, NuRD, and CoREST. Here, we demonstrate that double knockdown of <i>Rbbp4</i> and <i>7</i>, but not individually, causes embryonic lethality during the morula-to-blastocyst transition. Mechanistically, depletion of RBBP4 and 7 results in dysregulation of genes related to cell cycle, lineage development, and regulation of transcr"],"journal":["Epigenetics"],"pubmed_title":["Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development."],"pmcid":["PMC9543047"],"funding_grant_id":["No. 2020M671742"],"pubmed_authors":["Xiao L","Zhang K","Wang S","Luo L","Zhao P","Dang Y","Hu B"],"additional_accession":[]},"is_claimable":false,"name":"Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development.","description":"Preimplantation development is critical for reproductive successes in mammals. Thus, it is important to understand how preimplantation embryogenesis is regulated. As a key event of preimplantation development, epigenetic reprogramming has been widely studied, yet how epigenetic complexes regulate preimplantation development remains largely unknown. Retinoblastoma binding protein 4 (RBBP4) and 7 (RBBP7) are integral components of epigenetic complexes including SIN3A, NuRD, and CoREST. Here, we demonstrate that double knockdown of <i>Rbbp4</i> and <i>7</i>, but not individually, causes embryonic lethality during the morula-to-blastocyst transition. Mechanistically, depletion of RBBP4 and 7 results in dysregulation of genes related to cell cycle, lineage development, and regulation of transcr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T19:27:30.482Z","creation":"2025-04-04T19:27:30.482Z"},"accession":"S-EPMC9543047","cross_references":{"pubmed":["34709113"],"doi":["10.1080/15592294.2021.1999006"]}}