{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44(10)"],"submitter":["Shao YF"],"pubmed_abstract":["<h4>Background</h4>Initial primary head and neck cancer (IPHNC) is associated with second primary lung cancer (SPLC). We studied this association in a population with a high proportion of African American (AA) patients.<h4>Methods</h4>Patients with IPHNC and SPLC treated between 2000 and 2017 were reviewed for demographic, disease, and treatment-related characteristics and compared to age-and-stage-matched controls without SPLC. Logistic and Cox regression models were used to analyze the relationship of these characteristics with the development of SPLC and overall survival (OS).<h4>Results</h4>Eighty-seven patients and controls were compared respectively. AA race was associated with a significantly higher risk of developing SPLC (OR 2.92, 95% CI 1.35-6.66). After correcting for immortal time bias, patients with SPLC had a significantly lower OS when compared with controls (HR 0.248, 95% CI 0.170-0.362).<h4>Conclusions</h4>We show that AA race is associated with an increased risk of SPLC after IPHNC; reasons of this increased risk warrant further investigation."],"journal":["Head & neck"],"pagination":["2069-2076"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543059"],"repository":["biostudies-literature"],"pubmed_title":["African American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer."],"pmcid":["PMC9543059"],"pubmed_authors":["Kim S","Lin HS","Nagasaka M","Kim H","Farhat D","Yoo G","Hotaling J","Shao YF","Cramer JD","Raza SN","Sukari A"],"additional_accession":[]},"is_claimable":false,"name":"African American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer.","description":"<h4>Background</h4>Initial primary head and neck cancer (IPHNC) is associated with second primary lung cancer (SPLC). We studied this association in a population with a high proportion of African American (AA) patients.<h4>Methods</h4>Patients with IPHNC and SPLC treated between 2000 and 2017 were reviewed for demographic, disease, and treatment-related characteristics and compared to age-and-stage-matched controls without SPLC. Logistic and Cox regression models were used to analyze the relationship of these characteristics with the development of SPLC and overall survival (OS).<h4>Results</h4>Eighty-seven patients and controls were compared respectively. AA race was associated with a significantly higher risk of developing SPLC (OR 2.92, 95% CI 1.35-6.66). After correcting for immortal time bias, patients with SPLC had a significantly lower OS when compared with controls (HR 0.248, 95% CI 0.170-0.362).<h4>Conclusions</h4>We show that AA race is associated with an increased risk of SPLC after IPHNC; reasons of this increased risk warrant further investigation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T01:56:07.333Z","creation":"2025-04-05T20:12:53.544Z"},"accession":"S-EPMC9543059","cross_references":{"pubmed":["35713967"],"doi":["10.1002/hed.27107"]}}