biostudies-literatureUnknown44(10)Shao YF<h4>Background</h4>Initial primary head and neck cancer (IPHNC) is associated with second primary lung cancer (SPLC). We studied this association in a population with a high proportion of African American (AA) patients.<h4>Methods</h4>Patients with IPHNC and SPLC treated between 2000 and 2017 were reviewed for demographic, disease, and treatment-related characteristics and compared to age-and-stage-matched controls without SPLC. Logistic and Cox regression models were used to analyze the relationship of these characteristics with the development of SPLC and overall survival (OS).<h4>Results</h4>Eighty-seven patients and controls were compared respectively. AA race was associated with a significantly higher risk of developing SPLC (OR 2.92, 95% CI 1.35-6.66). After correcting for immortal time bias, patients with SPLC had a significantly lower OS when compared with controls (HR 0.248, 95% CI 0.170-0.362).<h4>Conclusions</h4>We show that AA race is associated with an increased risk of SPLC after IPHNC; reasons of this increased risk warrant further investigation.Head & neck2069-2076https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543059biostudies-literatureAfrican American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer.PMC9543059Kim SLin HSNagasaka MKim HFarhat DYoo GHotaling JShao YFCramer JDRaza SNSukari AfalseAfrican American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer.<h4>Background</h4>Initial primary head and neck cancer (IPHNC) is associated with second primary lung cancer (SPLC). We studied this association in a population with a high proportion of African American (AA) patients.<h4>Methods</h4>Patients with IPHNC and SPLC treated between 2000 and 2017 were reviewed for demographic, disease, and treatment-related characteristics and compared to age-and-stage-matched controls without SPLC. Logistic and Cox regression models were used to analyze the relationship of these characteristics with the development of SPLC and overall survival (OS).<h4>Results</h4>Eighty-seven patients and controls were compared respectively. AA race was associated with a significantly higher risk of developing SPLC (OR 2.92, 95% CI 1.35-6.66). After correcting for immortal time bias, patients with SPLC had a significantly lower OS when compared with controls (HR 0.248, 95% CI 0.170-0.362).<h4>Conclusions</h4>We show that AA race is associated with an increased risk of SPLC after IPHNC; reasons of this increased risk warrant further investigation.2022-01-01T00:00:00Z2022 Oct2025-04-22T01:56:07.333Z2025-04-05T20:12:53.544ZS-EPMC95430593571396710.1002/hed.27107